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1 Department of Comparative Biosciences, University of Wisconsin, Madison, WI, USA
2 Department of Population Health Sciences, University of Wisconsin, Madison, WI, USA
* To whom correspondence should be addressed. E-mail: bavisr{at}svm.vetmed.wisc.edu.
Developmental hyperoxia (1-4 wks of 60% O2) causes long-lasting impairment of hypoxic phrenic responses in rats. We hypothesized that shorter or less severe hyperoxic exposures would produce similar changes. Hypoxic phrenic responses were measured in 3-5 mo old, urethane-anesthetized rats exposed to 60% O2 for postnatal day 1 or week 1, or to 30% O2 for postnatal week 1. Whereas 1 d of 60% O2 had no lasting effects (P>0.05 vs. control), both 1 wk of 60% O2 and 1 wk of 30% O2 decreased adult hypoxic phrenic responses (P<0.05 vs. control), although the effects of 30% O2 were smaller. Hypoxic ventilatory responses (expressed as VE/VCO2) were also reduced in unanesthetized rats (5-10 mo old) exposed to 1 wk of 60% O2 during development (P<0.05). An age-dependent increase towards normal hypoxic phrenic responses was observed in rats exposed to 1 wk of 60% O2 (P<0.05), suggesting a degree of spontaneous recovery not observed following 1 mo of 60% O2. These data indicate that long-lasting effects of developmental hyperoxia depend on the level and duration of hyperoxic exposure.
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