| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Exercise and Sport Science, East Carolina University, Greenville, NC, USA
2 Exercise and Sport Science, East Carolina University, Greenville, NC, USA; Physiology, East Carolina University, Greenville, NC, USA
* To whom correspondence should be addressed. E-mail: gavint{at}mail.ecu.edu.
The skeletal muscle capillary supply is an important determinant of maximum exercise capacity and it is well known that endurance exercise training increases the muscle capillary supply. The muscle capillary supply and exercise-induced angiogenesis are regulated in part by vascular endothelial growth factor (VEGF). VEGF is produced by skeletal muscle cells and can be secreted into the circulation. We investigated whether there are differences in circulating plasma VEGF between sedentary individuals (SED) and well-trained endurance athletes (ET) at rest or in response to acute exercise. Eight ET males (VO2MAX: 63.8 ± 2.3 ml x kg-1 x min-1; maximum power output (PO): 409.4 ± 13.3 W) and 8 SED males (VO2MAX: 36.3 ± 2.1 ml x kg-1 x min-1; maximum PO 234.4 ± 13.3 W) exercised for 1 hr at 50% of maximum PO. Antecubital vein plasma was collected at rest and at 0, 2, and 4 hr post-exercise. Plasma VEGF was measured by ELISA analysis. Acute exercise significantly increased VEGF at 0 and 2 hr post-exercise in ET, but did not increase VEGF at any time point in SED. There was no difference in VEGF between ET and SED at any time point. When individual peak post-exercise VEGF was analyzed, exercise did increase VEGF independent of training status. In conclusion, exercise can increase plasma VEGF in both well-trained endurance athletes and sedentary males; however, there is considerable variation in the individual time of the peak VEGF response.
This article has been cited by other articles:
|
|
 |
|
  G Banfi, M M Corsi, and P Volpi Could platelet rich plasma have effects on systemic circulating growth factors and cytokine release in orthopaedic applications? Br. J. Sports Med., October 1, 2006; 40(10): 816 - 816. [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Prior, J. M. Hagberg, C. M. Paton, L. W. Douglass, M. D. Brown, J. C. McLenithan, and S. M. Roth DNA sequence variation in the promoter region of the VEGF gene impacts VEGF gene expression and maximal oxygen consumption Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H1848 - H1855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Morici, D. Zangla, A. Santoro, E. Pelosi, E. Petrucci, M. Gioia, A. Bonanno, M. Profita, V. Bellia, U. Testa, et al. Supramaximal exercise mobilizes hematopoietic progenitors and reticulocytes in athletes Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2005; 289(5): R1496 - R1503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. W. Jones, N. D. Eves, K. S. Courneya, B. K. Chiu, V. E. Baracos, J. Hanson, L. Johnson, and J. R. Mackey Effects of Exercise Training on Antitumor Efficacy of Doxorubicin in MDA-MB-231 Breast Cancer Xenografts Clin. Cancer Res., September 15, 2005; 11(18): 6695 - 6698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Suzuki Microvascular angioadaptation after endurance training with L-arginine supplementation in rat heart and hindleg muscles Exp Physiol, September 1, 2005; 90(5): 763 - 771. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. B Rossiter, R. A Howlett, H. H Holcombe, P. L Entin, H. E Wagner, and P. D Wagner Age is no barrier to muscle structural, biochemical and angiogenic adaptations to training up to 24 months in female rats J. Physiol., June 15, 2005; 565(3): 993 - 1005. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. H. Connolly, V. J. Caiozzo, F. Zaldivar, D. Nemet, J. Larson, S.-p. Hung, J. D. Heck, G. W. Hatfield, and D. M. Cooper Effects of exercise on gene expression in human peripheral blood mononuclear cells J Appl Physiol, October 1, 2004; 97(4): 1461 - 1469. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
