| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print February 8, 2002
J Appl Physiol, 10.1152/jap.01018.2001
Submitted on October 4, 2001
Accepted on January 29, 2002
1 Departments of Human Services, Medicine, and Health Evaluation Sciences, University of Virginia, Charlottesville, Virginia, USA
* To whom correspondence should be addressed. E-mail: alw2v{at}virginia.edu.
We previously reported that in young adult males GH release is related to exercise intensity in a linear dose-response manner (Pritzlaff et al. J Appl Physiol 87: 498-504, 1999). To investigate the effects of gender and exercise intensity on growth hormone (GH) release, 8 women (age = 24.3 ± 1.3 yr, ht = 171 ± 3.2 cm, wt = 63.6 ± 8.7 kg) were each tested on 6 randomly ordered occasions [1 control condition (C), 5 exercise conditions (Ex)]. Serum GH concentrations were measured in samples obtained at 10-min intervals between 0700h and 0900h (baseline) and 0900h and 1300h (exercise + recovery or control). Integrated GH concentrations (IGHC) were calculated by trapezoidal reconstruction. During Ex subjects exercised for 30 min (0900-0930h) at one of the following intensities [normalized to the lactate threshold (LT)]: 25 and 75% of the difference between LT and rest (0.25LT and 0.75LT, respectively), at LT, and at 25 and 75% of the difference between LT and VO2 peak (1.25LT and 1.75LT, respectively). No differences were observed among conditions for baseline IGHC. To determine if total (Ex + recovery) IGHC changed with increasing exercise intensity, the slopes associated with individual linear regression models were subjected to a Wilcoxon signed-rank test. To test for gender differences the present data in women were compared to the aforementioned previously published data in men. A Wilcoxon ranked-sums two-tailed test was used to analyze the slopes and intercepts from the regression models. Total IGHC [men: C = 250 ± 60; 0.25LT = 203 ± 69; 0.75LT = 448 ± 125; LT = 452 ± 119; 1.25LT = 512 ± 121; 1.75LT = 713 ± 115 µg.l-1.min-1) and women: C = 509 ± 126; 0.25LT = 799 ± 131; 0.75LT = 1013 ± 219; LT = 764 ± 97; 1.25LT = 954 ± 186; 1.75LT = 1459 ± 253 µg.L1.min-1)] increased linearly with increasing exercise intensity (P<0.05). The slope (men = 277 ± 48, women = 449 ± 80, P=0.08) and intercept (men = 198 ± 62 µg/L x min, women = 562 ± 112 µg/L x min, P=0.02) values for the relationship between total IGHC and exercise intensity were greater in women than in men. Deconvolution analysis (0700-1300h) revealed that regardless of gender, increasing exercise intensity resulted in a linear increase in the mass of GH secreted per pulse and summed GH production rate (P<0.05), with no changes in GH secretory pulse frequency or apparent half-life of elimination. Exercise reduced the half-duration of GH secretory burst in males, but not females. Gender comparisons revealed that women had greater basal (non-pulsatile) GH secretion across all conditions (P=0.04), more frequent GH secretory pulses (P=0.03), a greater GH secretory pulse amplitude (P=0.008), a greater production rate (P=0.0009), and a trend for a greater mass of GH/pulse (P=0.10) than men. We conclude that, in young adults, the GH secretory response to exercise is related to exercise intensity in a linear dose-response pattern. For each incremental increase in exercise intensity, the fractional stimulation of GH secretion is greater in women than men
This article has been cited by other articles:
|
|
 |
|
  J. Jurimae, T. Jurimae, and P. Purge Plasma Ghrelin Is Altered After Maximal Exercise in Elite Male Rowers Experimental Biology and Medicine, July 1, 2007; 232(7): 904 - 909. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Pierce, B. C. Clark, L. L. Ploutz-Snyder, and J. A. Kanaley Growth hormone and muscle function responses to skeletal muscle ischemia J Appl Physiol, December 1, 2006; 101(6): 1588 - 1595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wideman, L. Consitt, J. Patrie, B. Swearingin, R. Bloomer, P. Davis, and A. Weltman The impact of sex and exercise duration on growth hormone secretion J Appl Physiol, December 1, 2006; 101(6): 1641 - 1647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Weltman, J. Y. Weltman, C. P. Roy, L. Wideman, J. Patrie, W. S. Evans, and J. D. Veldhuis Growth hormone response to graded exercise intensities is attenuated and the gender difference abolished in older adults J Appl Physiol, May 1, 2006; 100(5): 1623 - 1629. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R Christ, M. Zehnder, C. Boesch, R. Trepp, P. E Mullis, P. Diem, and J. Decombaz The effect of increased lipid intake on hormonal responses during aerobic exercise in endurance-trained men. Eur. J. Endocrinol., March 1, 2006; 154(3): 397 - 403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Berggren, C. Ehrnborg, T. Rosen, L. Ellegard, B.-A. Bengtsson, and K. Caidahl Short-Term Administration of Supraphysiological Recombinant Human Growth Hormone (GH) Does Not Increase Maximum Endurance Exercise Capacity in Healthy, Active Young Men and Women with Normal GH-Insulin-Like Growth Factor I Axes J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3268 - 3273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-D. Qu, I. T. Gaw Gonzalo, M. Y. Al Sayed, P. Cohan, P. D. Christenson, R. S. Swerdloff, D. F. Kelly, and C. Wang Influence of Body Mass Index and Gender on Growth Hormone (GH) Responses to GH-Releasing Hormone Plus Arginine and Insulin Tolerance Tests J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1563 - 1569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Kraemer, R. J. Durand, E. O. Acevedo, L. G. Johnson, G. R. Kraemer, E. P. Hebert, and V. D. Castracane Rigorous Running Increases Growth Hormone and Insulin-Like Growth Factor-I Without Altering Ghrelin Experimental Biology and Medicine, March 1, 2004; 229(3): 240 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, J. Patrie, L. Wideman, M. Patterson, J. Y. Weltman, and A. Weltman Contrasting Negative-Feedback Control of Endogenously Driven and Exercise-Stimulated Pulsatile Growth Hormone Secretion in Women and Men J. Clin. Endocrinol. Metab., February 1, 2004; 89(2): 840 - 846. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M J Rennie Claims for the anabolic effects of growth hormone: a case of the Emperor's new clothes? Br. J. Sports Med., April 1, 2003; 37(2): 100 - 105. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
