Journal of Applied Physiology Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (February 15, 2002). doi:10.1152/japplphysiol.00993.2001
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
93/1/37    most recent
00993.2001v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shikanai, T.
Right arrow Articles by Drazen, J. M
Right arrow Search for Related Content
PubMed
Right arrow Articles by Shikanai, T.
Right arrow Articles by Drazen, J. M

Articles in PresS, published online ahead of print February 15, 2002
J Appl Physiol, 10.1152/jap.00993.2001
Submitted on September 28, 2001
Accepted on January 29, 2002

Sequence Variants in the Fc{epsilon}RI Alpha Chain Gene

Toshiki Shikanai1, Eric S Silverman2, Brian W Morse2, Craig M Lilly2, Hiroshi Inoue1, and Jeffrey M Drazen2*

1 Division of Pulmonary Medicine, Iwate Medical University, Morioka, Iwate, Japan
2 Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA

* To whom correspondence should be addressed. E-mail: jdrazen{at}nejm.org.

There is a relationship between IgE levels and expression of high-affinity IgE receptors (Fc{epsilon}RI). Since the alpha chain is the only portion of the receptor that binds directly to IgE, we reasoned that sequence variants in the Fc{epsilon}RI alpha gene may exist that alter these binding events. We screened all the exons and the promoter region of the Fc{epsilon}RI alpha chain gene with genomic DNA from 389 asthmatics and 341 normal control subjects for mutations using single-stranded conformational polymorphism (SSCP) analysis. No non-synonomous single nucleotide polymorphisms (SNPs) were identified in the coding region. Three SNPs were found in the promoter region: an A to C transversion at -770 from the translation start site; a G to A transition at -664; and a T to C transition at -335. No differences in allele frequencies were detected between asthmatics and controls. Homozygosity for the C variant at locus -335 was more common in Caucasian asthmatics with IgE levels in the lower quartile than in the upper quartile, p=0.032. An analysis of highly polymorphic SNPs indicated that this association is unlikely to be due to population substructure. We conclude that homozygosity for the C allele of Fc{epsilon}RI {alpha} chain variant is associated with lower IgE levels.




This article has been cited by other articles:


Home page
 CarcinogenesisHome page
J.-Y. Lee, A. K. Park, K.-M. Lee, S. K. Park, S. Han, W. Han, D.-Y. Noh, K.-Y. Yoo, H. Kim, S. J. Chanock, et al.
Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women
Carcinogenesis, September 1, 2009; 30(9): 1528 - 1531.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Kanada, N. Nakano, D. P. Potaczek, K. Maeda, N. Shimokawa, Y. Niwa, T. Fukai, M. Sanak, A. Szczeklik, H. Yagita, et al.
Two Different Transcription Factors Discriminate the -315C>T Polymorphism of the Fc{epsilon}RI{alpha} Gene: Binding of Sp1 to -315C and of a High Mobility Group-Related Molecule to -315T
J. Immunol., June 15, 2008; 180(12): 8204 - 8210.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
T. Oguma, L. J. Palmer, E. Birben, L. A. Sonna, K. Asano, and C. M. Lilly
Role of Prostanoid DP Receptor Variants in Susceptibility to Asthma
N. Engl. J. Med., October 21, 2004; 351(17): 1752 - 1763.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1966 by the American Physiological Society.