Journal of Applied Physiology
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J Appl Physiol (November 12, 2004). doi:10.1152/japplphysiol.00991.2004
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Submitted on September 9, 2004
Accepted on November 5, 2004

Inter- and intra-strain variation in mouse critical running speed

Veronique L Billat1*, Etienne Mouisel2, Natacha Roblot3, and Judith Melki3

1 Unite de Formation et de Recherche Fondamentale et Appliquee, Laboratory of Exercise Physiology, University of Evry, Evry, France
2 Unite de Formation et de Recherche Fondamentale et Appliquee, Laboratory of Exercise Physiology, University of Evry, Evry, France; Molecular Neurogenetics Laboratory, University of Evry, Evry, France
3 Molecular Neurogenetics Laboratory, University of Evry, Evry, France

* To whom correspondence should be addressed. E-mail: veronique.billat{at}wanadoo.fr.

With the generation of mouse models of human cardiovascular or neuromuscular disorders, the development of non-invasive methods to evaluate the physiological responses to exercise presents an important challenge. The possibility for determining critical speed (CS) in mouse model was examined according to strain (CD1, C57BL/6J, FVB/N) and gender. Sixty mice performed four exhaustive runs on a treadmill to determine their CS. Twenty one performed an incremental test to determine the velocity at the lactate threshold (vLT). CS was significantly different between the strains (P < 0.0001) but not between genders. Two measures of heritability showed that CS was partially heritable. CS was not significantly different from vLT. We conclude that CS, which reflects the aerobic capacity, can be determined in mice, as in humans and horses. Considering the intra-strain variability, CS could represent a valuable means for designing an optimal and individualized physical training in mice.




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