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Articles in PresS, published online ahead of print May 17, 2002
J Appl Physiol, 10.1152/jap.00986.2001
Submitted on September 26, 2001
Accepted on May 11, 2002
1 Department of Pediatric Pulmonology and Critical Care, Riley Hospital for Children//Indiana University, Indianapolis, Indiana, USA
* To whom correspondence should be addressed. E-mail: rtepper{at}iupui.edu.
Volume history is an important determinant of airway responsiveness. In healthy adults undergoing airway challenge, deep inspiration (DI) provides bronchodilating and bronchoprotective effects; however, the effectiveness of DI is limited in adult asthmatics. We hypothesized that when assessed under similar conditions, healthy infants have heightened airway reactivity compared to healthy adults, and that the effectiveness of DI is limited in infants. We compared the effect of DI upon reactivity by using full (DI) vs. partial (no DI) forced-expiratory maneuvers on two days in supine, healthy non-asthmatic infants (21) and adults (10). Reactivity was assessed by MCh doses that decreased FEF75 during a full maneuver and V'maxFRC during a partial maneuver by 30% from baseline. Reactivity in adults increased when DI was absent, whereas infant's reactivity was unchanged. Infants were more reactive than adults in the presence of DI; however, adult and infant reactivity was similar in its absence. Our findings indicate that healthy infants are more reactive than adults, and like adult asthmatics, do not benefit from DI; this difference may be an important characteristic of airway hyper-reactivity.
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