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J Appl Physiol (January 4, 2002). doi:10.1152/japplphysiol.00984.2001
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Articles in PresS, published online ahead of print January 4, 2002
J Appl Physiol, 10.1152/jap.00984.2001
Submitted on September 26, 2001
Accepted on January 4, 2002

Regulation of flow and wall shear stress in arteriolar networks of the hamster cheek pouch

Randall J Fox1 and Mary D Frame2*

1 Anesthesiology, University of Rochester Medical Center, Rochester, NY, USA; Biomedical Engineering, University of Rochester Medical Center, Rochester, NY, USA
2 Anesthesiology, University of Rochester Medical Center, Rochester, NY, USA; Biomedical Engineering, University of Rochester Medical Center, Rochester, NY, USA; Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, NY, USA

* To whom correspondence should be addressed. E-mail: molly_frame{at}urmc.rochester.edu.

Our purpose was to define arteriolar network hemodynamics during moderate increases in interstitial adenosine or NO, in the hamster (N=34, pentobarbital 70mg/kg) cheek pouch tissue. The network consists of a feed arteriole (~12µm diameter, ~800µm length) with 3-6 branches. Observations of diameter, red blood cell flux and velocity were obtained at the feed before the branch, and the branch. Baseline compared to suffused adenosine or nitroprusside (SNP) 10-9-10-5 M showed: First, diameter change was heterogeneous by agonist, did not reflect the expected dilatory response, and was related to location within the network. With adenosine, upstream branch points constricted and downstream dilated, even at 10-5M. With SNP, upstream branch points dilated, while downstream constricted. Second, with adenosine, changes in diameter, flux and velocity together resulted in no change in wall shear stress until 10-5M. Wall shear stress was not maintained at a constant level with N{omega}nitro-L-arginine (10-5M), suggesting a role for flow dependent diameter changes with adenosine. With SNP, diameter change correlated with the baseline (prior to SNP) shear stress conditions.




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