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J Appl Physiol (November 2, 2001). doi:10.1152/japplphysiol.00972.2001
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Articles in PresS, published online ahead of print November 2, 2001
J Appl Physiol, 10.1152/jap.00972.2001
Submitted on September 25, 2001
Accepted on October 30, 2001

Gasping and Autoresuscitation in the Developing Rat: Effect of Antecedent Intermittent Hypoxia

David Gozal1, Evelyne Gozal2*, Stephen R Reeves2, and Andrew J Lipton2

1 Pediatrics, University of Louisville, Louisville, KY, USA; Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA
2 Pediatrics, University of Louisville, Louisville, KY, USA

* To whom correspondence should be addressed. E-mail: david.gozal{at}louisville.edu.

Gasping is a critically important mechanism for autoresuscitation and survival during extreme tissue hypoxia. Evidence of antecedent hypoxia in sudden infant death syndrome suggests that intermittently occurring hypoxic episodes may modify gasping and autoresuscitation. To examine this issue, an intermittent hypoxia (IH) profile consisting of alternating room air and 10% oxygen every 90 sec was applied to pregnant Sprague-Dawley rats (E5-P0; IHRA; n=50), and to pups after a normal pregnancy (P1-P5; RAIH; n=50) as well as to control pups (RARA; n=50). At post-natal day 5, pups were exposed to 95%N2 balance 5%CO2, and gasping and the ability to autoresuscitate were assessed. Compared to RARA, IHRA- and RAIH-exposed pups had reduced number of gasps, decreased overall gasp duration, and were less likely to autoresuscitate upon introduction of room air to the breathing mixture during the last phase of gasping (P<0.001 vs. RARA). We conclude that both pre-natal and early post-natal IH adversely effect gasping and related survival mechanisms.




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