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J Appl Physiol (February 23, 2006). doi:10.1152/japplphysiol.00968.2005
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Submitted on August 8, 2005
Accepted on February 20, 2006

CO2/H+ Chemoreceptors in the Cerebellar Fastigial Nucleus do not Uniformly Affect Breathing of Awake Goats

P. F. Martino1*, M. R. Hodges1, S. Davis1, C. Opansky1, L. G. Pan2, K. Krause1, B. Qian1, and H. V. Forster3

1 Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA
2 Department of Physical Therapy, Marquette University, Milwaukee, WI, USA
3 Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA; Zablocki V.A. Medical Center, Milwaukee, WI, USA

* To whom correspondence should be addressed. E-mail: pmartino{at}mcw.edu.

Our objective in this study was to test the hypothesis that focal acidosis (FA) in the cerebellar fastigial nucleus (CFN) of awake goats arising from global brain acidosis induced by increasing inspired CO2 will increase breathing. Focal acidosis was created by reverse microdialysis (MD) of mock cerebral spinal fluid (mCSF), equilibrated with 6.4, 25, 50, or 80% CO2 through chronically implanted microtubules (cannula). Dialysis with 6.4% CO2 had no significant effects on any physiologic parameters. However, MD at higher levels of CO2 increased pulmonary ventilation (VI) in one group of studies and decreased VI in a second group and the difference between the groups was significant (t = 9.16, P < .001). In one group of studies (n = 8) FA with 50% and 80% CO2 significantly increased (P < .05) VI by 16% and 12%, respectively, and significantly increased (P < .05) heart rate by 13 and 9%, respectively. In contrast, in another group of studies (n = 6), FA with 25 and 50% CO2 significantly decreased (P < .05) VI by 7 and 10% respectively. In this group oxygen consumption (VO2) was decreased during dialysis with 80% CO2. Based on histology, we estimate that the increased and decreased responses were associated with FA primarily in the rostral and caudal CFN respectively. We conclude that there are CO2/H+ sensitive neurons in the CFN that do not uniformly affect breathing. In addition, the significant changes in HR and VO2 during FA indicatethat the CFN can also influence nonrespiratory related control systems.




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