Journal of Applied Physiology
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J Appl Physiol (March 7, 2003). doi:10.1152/japplphysiol.00968.2002
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Submitted on October 21, 2002
Accepted on March 4, 2003

Increased Susceptibility to Pseudomonas aeruginosa Infection Under Hindlimb Unloading Conditions

Hernan O Aviles1, Tesfaye Belay1, Kimberly Fountain1, Monique Vance1, and Gerald Sonnenfeld1*

1 Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA

* To whom correspondence should be addressed. E-mail: sonneng{at}msm.edu.

It has been reported that space flight conditions alter the immune system and resistance to infection. Ground-based models, including the hindlimb unloading model, have become important tools for increasing understanding of how space flight conditions can influence physiology. The objective of the current study was to determine the effect of hindlimb unloading on the susceptibility of mice to Pseudomonas aeruginosa infection. Hindlimb-unloaded and control mice were subcutaneously infected with one lethal dose 50 (LD50) of P. aeruginosa. Survival, bacterial organ load, antibody and corticosterone levels were compared among the groups. Hindlimb unloading had detrimental effects for infected mice. Animals in the hindlimb-unloaded group, compared to controls: a) showed significantly increased mortality and reduced time to death, b) increased levels of corticosterone, and c) were much less able to clear bacteria from the organs. These results suggest that hindlimb unloading may induce the production of corticosterone, which may play a critical role in the modulation of the immune system leading to increased susceptibility to P. aeruginosainfection.




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