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Articles in PresS, published online ahead of print February 1, 2002
J Appl Physiol, 10.1152/jap.00961.2001
Submitted on September 18, 2001
Accepted on January 16, 2002
1 Department of Health, Leisure, Exercise Science, Appalachian State University, Boone, NC, USA
2 Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
* To whom correspondence should be addressed. E-mail: niemandc{at}appstate.edu.
The purpose of this randomized study was to measure the influence of vitamin C (N=15) compared to placebo (N=13) supplementation on oxidative and immune changes in runners competing in an ultramarathon race. During the 7-d period prior to the race, subjects ingested in randomized, double-blind fashion three 500-mg tablets of vitamin C or placebo each day. On race day, blood samples were collected 1 h pre-race, after 32 km of running, and then again immediately post-race. During the race, runners received 1 l/h carbohydrate beverages with (150 mg/l) or without vitamin C in a double-blinded fashion. Subjects in both groups maintained an intensity of approximately 75% HRmax throughout the ultramarathon race, and ran a mean of 69 km (range 48 to 80 km) in 9.8 hours (range 5 to 12 hours). Plasma ascorbic acid was markedly higher in the vitamin C compared to placebo group pre-race, and rose more strongly in the vitamin C group during the race (post-race, 3.21±0.29 and 1.28±0.12 µg/100 µl, respectively, P<0.001). No significant group or interaction effects were measured for lipid hydroperoxide and F2-isoprostane, but both oxidative measures rose significantly during the ultramarathon race. No significant group or interaction effects were measured for immune cell counts, plasma IL-6, IL-10, IL-1ra, or IL-8 concentrations, or mitogen-stimulated lymphocyte proliferation and IL-2 and IFN-
production. No significant correlations were found between post-race plasma vitamin C, oxidative, and immune measures except for a positive correlation between F2-isoprostane and plasma IL-10 (r=0.42, P=0.026). These data indicate that vitamin C supplementation in carbohydrate-fed runners does not serve as a countermeasure to oxidative and immune changes during or following a competitive ultramarathon race.
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