Journal of Applied Physiology Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 QUICK SEARCH:   [advanced]


     


J Appl Physiol (November 15, 2007). doi:10.1152/japplphysiol.00953.2007
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
104/3/853    most recent
00953.2007v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ferreira, L. F.
Right arrow Articles by Reid, M. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ferreira, L. F.
Right arrow Articles by Reid, M. B.
Submitted on September 9, 2007
Accepted on November 9, 2007

MUSCLE-DERIVED ROS AND THIOL REGULATION IN MUSCLE FATIGUE

Leonardo F. Ferreira1 and Michael B. Reid1*

1 Department of Physiology, University of Kentucky, Lexington, Kentucky, United States

* To whom correspondence should be addressed. E-mail: michael.reid{at}uky.edu.

Muscles produce oxidants, including reactive oxygen species (ROS) and reactive nitrogen species (RNS), from a variety of intracellular sources. Oxidants are detectable in muscle at low levels during rest and at higher levels during contractions. RNS depress force production but do not appear to cause fatigue of healthy muscle. In contrast, muscle-derived ROS contribute to fatigue since loss of function can be delayed by ROS-specific antioxidants. Thiol regulation appears to be important in this biology. Fatigue causes oxidation of glutathione, a thiol antioxidant in muscle fibers, and is reversed by thiol-specific reducing agents. N-acetylcysteine (NAC), a drug that supports glutathione synthesis, has been shown to lessen oxidation of cellular constituents and delay muscle fatigue. In humans, NAC pretreatment improves performance of limb and respiratory muscles during fatigue protocols and extends time-to-task failure during volitional exercise. These findings highlight the importance of ROS and thiol chemistry in fatigue, show the feasibility of thiol-based countermeasures, and identify new directions for mechanistic and translational research.




This article has been cited by other articles:


Home page
J. Appl. Physiol.Home page
S. J. Bailey, P. Winyard, A. Vanhatalo, J. R. Blackwell, F. J. DiMenna, D. P. Wilkerson, J. Tarr, N. Benjamin, and A. M. Jones
Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans
J Appl Physiol, October 1, 2009; 107(4): 1144 - 1155.
[Abstract] [Full Text] [PDF]


Home page
Evid Based Complement Alternat MedHome page
S. Toda
Investigation of Electroacupuncture and Manual Acupuncture on Carnitine and Glutathione in Muscle
Evid. Based Complement. Altern. Med., July 10, 2009; (2009) nep071v1.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
L. F. Ferreira, L. A. A. Gilliam, and M. B. Reid
L-2-Oxothiazolidine-4-carboxylate reverses glutathione oxidation and delays fatigue of skeletal muscle in vitro
J Appl Physiol, July 1, 2009; 107(1): 211 - 216.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. ProteomicsHome page
C. Fu, C. Wu, T. Liu, T. Ago, P. Zhai, J. Sadoshima, and H. Li
Elucidation of Thioredoxin Target Protein Networks in Mouse
Mol. Cell. Proteomics, July 1, 2009; 8(7): 1674 - 1687.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
M. A. Chambers, J. S. Moylan, J. D. Smith, L. J. Goodyear, and M. B. Reid
Stretch-stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP-kinase
J. Physiol., July 1, 2009; 587(13): 3363 - 3373.
[Abstract] [Full Text] [PDF]


Home page
Exp PhysiolHome page
T. F. Reardon and D. G. Allen
Iron injections in mice increase skeletal muscle iron content, induce oxidative stress and reduce exercise performance
Exp Physiol, June 1, 2009; 94(6): 720 - 730.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1948 by the American Physiological Society.