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J Appl Physiol (November 16, 2001). doi:10.1152/japplphysiol.00929.2001
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Articles in PresS, published online ahead of print November 16, 2001
J Appl Physiol, 10.1152/jap.00929.2001
Submitted on September 6, 2001
Accepted on November 13, 2001

Acute ethanol increases angiogenic growth factor gene expression in rat skeletal muscle

Timothy P Gavin1* and Peter D Wagner1

1 Medicine, University of California, San Diego, La Jolla, CA, none

* To whom correspondence should be addressed. E-mail: gavint{at}mail.ecu.edu.

Moderate ethanol consumption demonstrates a protective effect against cardiovascular disease (CVD) and improves insulin sensitivity, possibly through angiogenesis. We investigated if 1) ethanol would increase skeletal muscle growth factor gene expression; and 2) the effects of ethanol on skeletal muscle growth factor gene expression were independent of exercise-induced growth factor gene expression. Female Wistar rats were used. Four groups (saline + rest; saline + exercise; 17 mmol/kg ethanol + rest; and 17 mmol/kg ethanol + exercise) were used to measure the growth factor response to acute exercise and ethanol administration. VEGF, TGFb1, bFGF, Flt-1, and Flk-1 mRNA were analyzed from the left gastrocnemius by quantitative Northern blot. Ethanol increased VEGF, TGFb1, bFGF, and Flt-1 mRNA at rest and following acute exercise. Ethanol increased resting Flk-1 mRNA. Ethanol increased bFGF mRNA independently of exercise. These findings suggest that: 1) ethanol can increase skeletal muscle angiogenic growth factor gene expression and 2) the mechanisms responsible for the ethanol induced increases in VEGF, TGFb1, and Flt-1 mRNA appear to be different than those responsible for exercise-induced regulation. Therefore, these results provide evidence in adult rat tissue that the protective cardiovascular effects of moderate ethanol consumption may result in part through the increase of angiogenic growth factors.




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