Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (December 23, 2004). doi:10.1152/japplphysiol.00916.2004
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
98/4/1458    most recent
00916.2004v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hasegawa, H.
Right arrow Articles by Meeusen, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hasegawa, H.
Right arrow Articles by Meeusen, R.
Submitted on August 31, 2004
Accepted on December 17, 2004

Inhibition of the preoptic area and anterior hypothalamus by tetrodotoxin alters thermoregulatory functions in exercising rats

Hiroshi Hasegawa1*, Takayuki Ishiwata2, Takehito Saito2, Toru Yazawa2, Yasutsugu Aihara2, and Romain Meeusen3

1 Laboratory of Exercise Physiology, Hiroshima University, Higashihiroshima, Hiroshima, Japan; Department of Human Physiology and Sportsmedicine, Vrije Universiteit Brussel, Brussels, Belgium
2 Department of Biology, Tokyo Metropolitan University, Graduate School of Science, Hachioji, Tokyo, Japan
3 Department of Human Physiology and Sportsmedicine, Vrije Universiteit Brussel, Brussels, Belgium

* To whom correspondence should be addressed. E-mail: hhasegaw{at}vub.ac.be.

We have previously demonstrated a functional role of the preoptic area and anterior hypothalamus (PO/AH) in thermoregulation in freely moving rats at various temperature conditions using microdialysis and biotelemetry methods. In the present study, we perfused tetrodotoxin (TTX) solution into the PO/AH to investigate whether this manipulation can modify thermoregulation in exercising rats. Male Wistar rats were trained for 3wks by treadmill running. Body core temperature (Tb), heart rate (HR) and tail skin temperature (Ttail) were measured. Rats ran for 120 min at speed of 10 m min-1, with TTX (5 µM) perfused into the left PO/AH during the last 60 min of exercise through a microdialysis probe (control, n=12; TTX, n=12). Tb, HR and Ttail increased during the first-20 min of exercise. Thereafter, Tb, HR and Ttail were stable in both groups. Perfusion of TTX into the PO/AH evoked an additional rise in Tb (control: 38.2 ± 0.1 °C, TTX: 39.3 ± 0.2 °C, p < 0.001) with a significant decrease in Ttail (control: 31.2 ± 0.5 °C, TTX: 28.3 ± 0.7 °C, p < 0.01) and a significant increase in HR (control: 425.2 ± 12 bpm, TTX: 502.1 ± 13 bpm, p < 0.01).These results suggest that the TTX-induced hyperthermia to be the result of both an impairment of heat loss and an elevation of heat production during exercise. We therefore propose the PO/AH as an important thermoregulatory site in the brain during exercise.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
L. Nybo
Hyperthermia and fatigue
J Appl Physiol, March 1, 2008; 104(3): 871 - 878.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. H. R. Leite, A. C. R. Lacerda, U. Marubayashi, and C. C. Coimbra
Central angiotensin AT1-receptor blockade affects thermoregulation and running performance in rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R603 - R607.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Hasegawa, R. Meeusen, S. Sarre, M. Diltoer, M. F. Piacentini, and Y. Michotte
Acute dopamine/norepinephrine reuptake inhibition increases brain and core temperature in rats
J Appl Physiol, October 1, 2005; 99(4): 1397 - 1401.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1966 by the American Physiological Society.