| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia
2 Zoology, La Trobe University, Melbourne, Victoria, Australia; , Australia
3 Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
* To whom correspondence should be addressed. E-mail: davida{at}physiol.usyd.edu.au.
Impaired calcium release from the sarcoplasmic reticulum (SR) has been identified as a contributor to fatigue in isolated skeletal muscle fibers. The functional importance of this phenomenon can be quantified by the use of agents, such as caffeine, which can increase SR Ca2+ release during fatigue. A number of possible mechanisms for impaired calcium release have been proposed. These include reduction in the amplitude of the action potential, potentially caused by extracellular K+ accumulation, which may reduce voltage sensor activation but is counteracted by a number of mechanisms in intact animals. Reduced effectiveness of SR Ca2+ channel opening is caused by the fall in intracellular ATP and the rise in Mg2+ concentrations which occur during fatigue. Reduced Ca2+ available for release within the SR can occur if inorganic phosphate enters the SR and precipitates with Ca2+. Further progress requires the development of methods which can identify impaired SR Ca2+ release in intact, blood-perfused muscles and which can distinguish between the various mechanisms proposed.
This article has been cited by other articles:
|
|
 |
|
  S. J. Choi and J. J. Widrick Combined effects of fatigue and eccentric damage on muscle power J Appl Physiol, October 1, 2009; 107(4): 1156 - 1164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Place, T. Yamada, S.-J. Zhang, Håk. Westerblad, and J. D. Bruton High temperature does not alter fatigability in intact mouse skeletal muscle fibres J. Physiol., October 1, 2009; 587(19): 4717 - 4724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. I. Rosser, B. Walsh, and M. C. Hogan Effect of physiological levels of caffeine on Ca2+ handling and fatigue development in Xenopus isolated single myofibers Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2009; 296(5): R1512 - R1517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Sidhu, D. J. Bentley, and T. J. Carroll Locomotor exercise induces long-lasting impairments in the capacity of the human motor cortex to voluntarily activate knee extensor muscles J Appl Physiol, February 1, 2009; 106(2): 556 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Allen Fatigue in working muscles J Appl Physiol, February 1, 2009; 106(2): 358 - 359. [Full Text] [PDF]
|
|
|
|
|
|
M. Amann, L. T. Proctor, J. J. Sebranek, D. F. Pegelow, and J. A. Dempsey Opioid-mediated muscle afferents inhibit central motor drive and limit peripheral muscle fatigue development in humans J. Physiol., January 1, 2009; 587(1): 271 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Green, E. Bombardier, T. A. Duhamel, R. D. Stewart, A. R. Tupling, and J. Ouyang Metabolic, enzymatic, and transporter responses in human muscle during three consecutive days of exercise and recovery Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2008; 295(4): R1238 - R1250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Place, T. Yamada, J. D. Bruton, and H. Westerblad Interpolated twitches in fatiguing single mouse muscle fibres: implications for the assessment of central fatigue J. Physiol., June 1, 2008; 586(11): 2799 - 2805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Amann, S. M. Marcora, L. Nybo, T. A. Duhamel, T. D. Noakes, V. Jaquinandi, J. L. Saumet, P. Abraham, B. T. Ameredes, M. Burnley, et al. Viewpoint: Fatigue mechanisms determining exercise performance: integrative physiology is systems physiology. J Appl Physiol, May 1, 2008; 104(5): 1543 - 1544. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
