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1 Departments of Anatomy and Physiology and Kinesiology, Kansas State University, Manhattan, Kansas, USA
* To whom correspondence should be addressed. E-mail: tbarsto{at}ksu.edu.
The near-infrared spectroscopy (NIRS) signal (deoxy-hemoglobin concentration; [HHb]) reflects the dynamic balance between muscle capillary blood flow (Qcap) and muscle oxygen uptake (VO2m) in the microcirculation. The purposes of the present study were to estimate the time course of Qcap from the kinetics of the primary component of pulmonary VO2 (VO2p) and [HHb] throughout exercise, and compare the Qcap kinetics with the VO2p kinetics. Nine subjects performed moderate- (M; below Lactate Threshold, LT) and heavy-intensity (H, above LT) constant work rate tests. VO2p (L.min-1) was measured breath-by-breath and [HHb] (µM) was measured by NIRS during the tests. The time course of Qcap was estimated from the rearrangement of the Fick equation [Qcap = VO2m/(CaO2 -CvO2)] using VO2p (primary comp.) and [HHb] as proxies of VO2m and (CaO2 -CvO2), respectively. The kinetics of [HHb] (
+TD [HHb]; M = 17.8 ± 2.3 s and H = 13.7 ± 1.4 s) were significantly (P < 0.001) faster than the kinetics of
VO2 (P; M = 25.5 ± 8.8 s and H = 25.6 ± 7.2 s) and Qcap (mean response time, MRT; M = 25.4 ± 9.1 s and H = 25.7 ± 7.7 s). However, there was no significant difference between MRT-Qcap and P-VO2 for both intensities (P = 0.99), and these parameters were significantly correlated (M and
H; r = 0.99; P < 0.001). In conclusion, we have proposed a new method to noninvasively approximate Qcap kinetics in humans during exercise. The resulting overall Qcap kinetics appeared to be tightly coupled to the temporal profile of VO2m.
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