Journal of Applied Physiology
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J Appl Physiol (November 12, 2004). doi:10.1152/japplphysiol.00906.2004
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Submitted on August 20, 2004
Accepted on November 10, 2004

Elevated body temperature enhances the laryngeal chemoreflex in decerebrate piglets

Aidan K Curran1, Luxi Xia1, J. C Leiter1*, and Donald J Bartlett Jr.1

1 Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA

* To whom correspondence should be addressed. E-mail: james.c.leiter{at}dartmouth.edu.

Hyperthermia and reflex apnea may both contribute to sudden infant death syndrome (SIDS). Therefore, we investigated the effect of increased body temperature on the inhibition of breathing produced by water injected into the larynx, which elicits the laryngeal chemoreflex (LCR). We studied decerebrated, vagotomized, neonatal piglets aged 3-15 days. Blood pressure, end-tidal CO2, body temperature and phrenic nerve activity were recorded. To elicit the LCR, we infused 0.1 ml distilled water through a polyethylene tube passed through the nose and positioned just rostral to the larynx. Three to five LCR trials were performed with the piglet at normal body temperature. The animal's core body temperature was raised by ~2.5 °C, and 3-5 LCR trials were performed before the animal was cooled and 3-5 LCR trials were repeated. The respiratory inhibition associated with the LCR was substantially prolonged when body temperature was elevated. Thus, elevated body temperature may contribute to the pathogenesis of SIDS by increasing the inhibitory effects of the LCR.




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