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1 Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
2 Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA
* To whom correspondence should be addressed. E-mail: Connie.Hsia{at}utsouthwestern.edu.
To determine if all trans-retinoic acid (RA) treatment enhances lung function during compensatory lung growth in fully mature animals, adult male dogs (n=4) received RA 2 mg/kg/day p.o. 4 days/wk beginning the day following right PNX (R-PNX, 55-58% resection). Litter-matched male R-PNX controls (n=4) received placebo. After 3 months, transpulmonary pressure (TPP)-lung volume relationship, diffusing capacity for carbon monoxide (DLCO) and nitric oxide (DLNO), cardiac output and septal volume (Vtiss-RB) were measured under anesthesia by a rebreathing technique at two lung volumes. Lung air and tissue volumes (Vair-CT and Vtiss-CT) were also measured from high-resolution computerized tomographic (CT) scans at a constant TPP. In RA-treated dogs compared to controls, TPP-lung volume relationships were similar. DLCO and DLNO were significantly impaired at a lower lung volume but similar at a high lung volume. While Vtiss-RB was significantly lower at both lung volumes in RA-treated animals, Vair-CT and Vtiss-CT were not different between groups; results suggest uneven distribution of ventilation consistent with distortion of alveolar geometry and/or altered small airway function induced by RA. We conclude that RA does not improve resting pulmonary function during the early months following R-PNX despite histological evidence of its action in enhancing alveolar cellular growth in the remaining lung.
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