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Articles in PresS, published online ahead of print April 5, 2002
J Appl Physiol, 10.1152/jap.00899.2001
Submitted on August 29, 2001
Accepted on March 8, 2002
1 Prince of Wales Medical Research Institute, Sydney, NSW, Australia; Sahlgren University Hospital, Institute for Clinical Neuroscience, Goteborg, Sweden
2 Department of Respiratory Medicine, Prince of Wales Hospital, Sydney, NSW, Australia
3 Prince of Wales Medical Research Institute, Sydney, NSW, Australia
* To whom correspondence should be addressed. E-mail: vg.macefield{at}unsw.edu.au.
In congestive heart failure (CHF) muscle sympathetic activity (MSNA) is greatly elevated, but we have shown that single muscle vasoconstrictor neurons primarily fire only once per cardiac interval - as in normal subjects. We tested the hypothesis that this firing pattern is maintained in other states of sympathoexcitation, in this study using patients with the obstructive sleep apnea syndrome (OSAS). Unitary recordings were made from muscle vasoconstrictor neurons in 8 awake OSAS patients. The average firing frequency of 12 units was 0.96 Hz and the firing probability 51%, similar to previous observations in CHF (0.98Hz, 55%) but higher than in healthy subjects (0.40Hz, 31%). However, the percentages of cardiac intervals in which neurons generated 1, 2, 3 or 4 spikes were 59, 27, 10 and 3% in OSAS, compared with 71, 18, 7 and 2% in CHF and 73, 18, 5 and 3 in healthy subjects. Thus, the firing pattern is different in OSAS and CHF, thereby rejecting the hypothesis: while in both conditions individual neurones show an increase in firing probability, in OSAS patients they also fire more often within a cardiac interval. It is likely that differences may also be apparent in other states of sympathoexcitation.
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