Journal of Applied Physiology AJP: Renal Physiology
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J Appl Physiol (February 8, 2002). doi:10.1152/japplphysiol.00895.2001
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Articles in PresS, published online ahead of print February 8, 2002
J Appl Physiol, 10.1152/jap.00895.2001
Submitted on August 29, 2001
Accepted on January 23, 2002

Enhanced baroreflex-mediated inhibition of respiration after muscimol dialysis in the rostral ventral medulla

Aidan K Curran1*, Daniel M Peraza1, Cheryl A Elinsky1, and James C Leiter2

1 Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
2 Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA; Department of Medicine, Dartmouth Medical School, Lebanon, NH, USA

* To whom correspondence should be addressed. E-mail: aidan.k.curran{at}dartmouth.edu.

The rostral ventral medulla (RVM) may be important in the control of cardiorespiratory interactions. We hypothesized that inhibition of the RVM would enhance inhibition of breathing associated with transient blood pressure elevations. In 25 piglets 3-16 days of age, we studied the effect of acutely increasing the blood pressure by systemic infusion of phenylephrine on respiratory activity before and after inhibition of neural activity in the RVM by dialysis of 10 mM muscimol, a GABAA receptor agonist. Muscimol dialysis through probes that were placed along the ventral medullary surface from ~1mm rostral to the facial nucleus to ~0.5mm caudal to the facial nucleus augmented the respiratory inhibition associated with acute increases in blood pressure. No similar enhancement of respiratory inhibition after phenylephrine treatment was seen in 6 control animals that did not receive muscimol dialysis. We conclude that the piglet RVM participates in cardiorespiratory interactions, and dysfunction of homologous regions in the human infant could lead to cardiorespiratory instability and may be involved in the pathogenesis of SIDS.




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