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1 Biomedical Engineering, Boston University, Boston, Massachusetts, United States; Respiratory Medicine, Nagoya University School of Medicine, Nagoya, Aichi, Japan
2 Biomedical Engineering, Boston University, Boston, Massachusetts, United States
3 Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States
* To whom correspondence should be addressed. E-mail: bsuki{at}bu.edu.
We measured the mechanical properties of the respiratory system of C57BL/6 mice using the optimal ventilation waveform (OVW) method in closed- and open-chest conditions at different positive end-expiratory pressures. The tissue damping (G), tissue elastance (H), airway resistance (Raw), and hysteresivity were obtained by fitting the impedance data to three different models, a constant phase model by Hantos et al. (J Appl Physiol 72:168-178,1992), a heterogeneous airway resistance model by Suki et al. (J Appl Physiol 82:1349-1359,1997), and a heterogeneous tissue elastance model by Ito et al. (J Appl Physiol 97:204-212,2004). Both in the closed- and open-chest conditions, G and hysteresivity were the lowest and Raw the highest in the heterogeneous airway resistance model, and G and H were the largest in the heterogeneous tissue elastance model. Values of G, Raw, and hysteresivity were significantly higher in the closed-chest than in the open-chest condition. However, H was not affected by the conditions. When the tidal volume of the OVW was decreased from 8 to 4 ml/kg in the closed-chest condition, G and hysteresivity significantly increased, but there were smaller changes in H or Raw. In summary, values of the obtained mechanical properties varied among these models primarily due to heterogeneity. Moreover, the mechanical parameters were significantly affected by the chest wall and tidal volume in mice. Contribution of the chest wall and heterogeneity to the mechanical properties should be carefully considered in physiological studies in which partitioning of airway and tissue properties are attempted.
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