Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (January 3, 2003). doi:10.1152/japplphysiol.00881.2002
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
94/4/1583    most recent
00881.2002v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Harper, R. M
Right arrow Articles by Yan-Go, F. L
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harper, R. M
Right arrow Articles by Yan-Go, F. L
Submitted on September 24, 2002
Accepted on December 30, 2002

FMRI Responses to Cold Pressor Challenges in Control and Obstructive Sleep Apnea Subjects

Ronald M Harper1*, Paul M Macey2, Luke A Henderson2, Mary A Woo3, Katherine E Macey2, Robert C Frysinger2, Jeffry R Alger4, Khanh P Nguyen2, and Frisca L Yan-Go5

1 Neurobiology, University of California at Los Angeles, Los Angeles, CA, USA; Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA
2 Neurobiology, University of California at Los Angeles, Los Angeles, CA, USA
3 School of Nursing, University of California at Los Angeles, Los Angeles, CA, USA
4 Radiology, University of California at Los Angeles, Los Angeles, CA, USA; Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA
5 Neurology, University of California at Los Angeles, Los Angeles, CA, USA

* To whom correspondence should be addressed. E-mail: rharper{at}ucla.edu.

Obstructive Sleep Apnea (OSA) patients exhibit altered sympathetic outflow, which may reveal mechanisms underlying the syndrome. We used functional magnetic resonance imaging in 16 control and 10 OSA subjects, free of cardiovascular or mood-altering drugs, to examine neural responses to a forehead cold pressor challenge, which elicits respiratory slowing, bradycardia and enhanced sympathetic outflow. The magnitude of cold-induced bradycardia was smaller, and respiratory slowing showed greater inter-subject variability and reached a nadir later in OSA patients. Both groups showed similar signal changes to cold stimulation in multiple brain sites. However, signal increases emerged in OSA over controls in anterior and posterior cingulate, and cerebellar and frontal cortex, while signals markedly declined in the ventral thalamus, hippocampus, and insula rather than rising as in controls; anomalous responses often paralleled changes in breathing and heart rate. Medullary, midbrain areas, lentiform and cerebellar dentate nuclei also showed lower signals in OSA cases. Cold pressor physiologic responses are modified in OSA, and may result from both diminished and exaggerated responses in multiple brain structures.




This article has been cited by other articles:


Home page
 Journal of the American Dental AssociationHome page
M. S. Simmons and G. T. Clark
The Potentially Harmful Medical Consequences of Untreated Sleep-Disordered Breathing: The Evidence Supporting Brain Damage
J Am Dent Assoc, May 1, 2009; 140(5): 536 - 542.
[Abstract] [Full Text] [PDF]

Home page
 PsychosomaticsHome page
D. Berge, P. Salgado, A. Rodriguez, and A. Bulbena
Onset of Mania After CPAP in a Man With Obstructive Sleep Apnea
Psychosomatics, September 1, 2008; 49(5): 447 - 449.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. M. Rector, C. A. Richard, and R. M. Harper
Cerebellar fastigial nuclei activity during blood pressure challenges
J Appl Physiol, August 1, 2006; 101(2): 549 - 555.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. Hashimoto, T. Ono, E.-i. Honda, K. Maeda, H. Shinagawa, S. Tsuiki, S. Hiyama, T. Kurabayashi, and K. Ohyama
Effects of mandibular advancement on brain activation during inspiratory loading in healthy subjects: a functional magnetic resonance imaging study
J Appl Physiol, February 1, 2006; 100(2): 579 - 586.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. G. Macefield, S. C. Gandevia, and L. A. Henderson
Neural sites involved in the sustained increase in muscle sympathetic nerve activity induced by inspiratory capacity apnea: a fMRI study
J Appl Physiol, January 1, 2006; 100(1): 266 - 273.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. A. Haxhiu, P. Kc, C. T. Moore, S. S. Acquah, C. G. Wilson, S. I. Zaidi, V. J. Massari, and D. G. Ferguson
Brain stem excitatory and inhibitory signaling pathways regulating bronchoconstrictive responses
J Appl Physiol, June 1, 2005; 98(6): 1961 - 1982.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. J. O'Donoghue, R. S. Briellmann, P. D. Rochford, D. F. Abbott, G. S. Pell, C. H. P. Chan, N. Tarquinio, G. D. Jackson, and R. J. Pierce
Cerebral Structural Changes in Severe Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., May 15, 2005; 171(10): 1185 - 1190.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. E. Macey, P. M. Macey, M. A. Woo, R. K. Harper, J. R. Alger, T. G. Keens, and R. M. Harper
fMRI signal changes in response to forced expiratory loading in congenital central hypoventilation syndrome
J Appl Physiol, November 1, 2004; 97(5): 1897 - 1907.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. A. Henderson, C. A. Richard, P. M. Macey, M. L. Runquist, P. L. Yu, J.-P. Galons, and R. M. Harper
Functional magnetic resonance signal changes in neural structures to baroreceptor reflex activation
J Appl Physiol, February 1, 2004; 96(2): 693 - 703.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. A. Woo, P. M. Macey, G. C. Fonarow, M. A. Hamilton, and R. M. Harper
Regional brain gray matter loss in heart failure
J Appl Physiol, August 1, 2003; 95(2): 677 - 684.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1966 by the American Physiological Society.