Journal of Applied Physiology AJP: Heart and Circulatory Physiology
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J Appl Physiol (November 27, 2002). doi:10.1152/japplphysiol.00879.2002
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Articles in PresS, published online ahead of print November 27, 2002
J Appl Physiol, 10.1152/jap.00879.2002
Submitted on September 24, 2002
Accepted on November 13, 2002

Reduced exercise a - v O2 difference in type 2 diabetics

James C Baldi1*, James L Aoina1, Helen C Oxenham2, Warwick Bagg2, and Robert N Doughty2

1 Department of Sport and Exercise Science, The University of Auckland, Auckland, New Zealand
2 Department of Cardiovascular Research, School of Medicine, The University of Auckland, Auckland, New Zealand

* To whom correspondence should be addressed. E-mail: j.baldi{at}auckland.ac.nz.

Individuals with type 2 diabetes have lower maximal oxygen consumption (VO2max) than sedentary non-diabetic individuals. This study aimed to determine whether the lower VO2max in diabetic subjects was due to a reduction in maximal cardiac output and/or peripheral oxygen extraction. Eleven type 2 diabetic (DIAB) and 12 non-diabetic (CON) subjects matched for age and body composition who had not exercised for two years performed a bicycle ergometer exercise test to determine VO2max, followed by assessment of submaximal and maximal cardiac output (Qmax) and arteriovenous oxygen difference (a-vO2). Maximal workload, VO2max and maximal a-vO2 were lower in type 2 diabetics (p < 0.05). Qmax (11.2 L/min CON vs. 10.0 L/min DIAB) was low in both groups, but not significantly different (p > 0.05). Submaximal VO2 and heart rate were lower at several workloads in DIAB subjects, however RER was similar between groups at all workloads. V O2max was linearly correlated with maximal a-vO2, but not Qmax in DIAB subjects. These data suggest that a reduction in maximal a - vO2 contributes to a decreased VO2 in type 2 diabetic individuals.




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