Journal of Applied Physiology
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J Appl Physiol (February 28, 2003). doi:10.1152/japplphysiol.00876.2002
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Submitted on September 23, 2002
Accepted on February 24, 2003

Stretch-activated ion channels and c-fos expression remain active following repeated eccentric bouts

Todd A McBride1*

1 Department of Biology, California State University, Bakersfield, CA, USA

* To whom correspondence should be addressed. E-mail: tmcbride{at}csub.edu.

This study was undertaken to measure the response of stretch activated ion channels (SAC) and transcript levels of the oncogene c-fos to separate bouts of eccentric contractions (EC). It was hypothesized that SAC in rat skeletal muscle would contribute to resting membrane potential depolarization following separate repeated bouts of EC. Blocking SAC during an EC training regime also tested the necessity of SAC for a training response. It was also hypothesized that transcript levels of c-fos would be maximally elevated following the first exposure to EC, and diminish with repeated exposures. The results indicate less depolarization following multiple bouts of EC, which could be reversed by blocking the SAC. Transcript levels of c-fos were elevated to a similar degree following either a single or multiple exposures to EC. EC training resulted in significant increases in contractile force and muscle wet and dry weights in non treated animals. Training in the presence of the SAC channel blocker streptomycin produced similar changes in contractile force without changes in muscle weight. SAC and c-fos are activated following several exposures to EC, and therefore remain as possible signals in EC training responses.




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