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1 Department of Physical Sciences, University of Helsinki, Helsinki, FIN-00014, Finland
2 European Synchrotron Radiation Facility, Grenoble, F-38043, France; Universite Joseph Fourier, Grenoble, UMR CNRS 5525, France
3 European Synchrotron Radiation Facility, Grenoble, F-38043, France
4 Canadian Light Source, Inc, Saskatoon, SK S7N 0X4, Canada
5 Department of Clinical Physiology and Nuclear Medicine, Helsinki University Central Hospital, Helsinki, FIN-00029, Finland
* To whom correspondence should be addressed. E-mail: liisa.porra{at}helsinki.fi.
A respiration-gated Synchrotron Radiation Computed Tomography (SRCT) technique, which allows visualization and direct quantification of inhaled stable xenon (Xe) gas, was used to study the effect of tidal volume (VT) on regional lung ventilation. High-resolution maps (pixel size 0.35mm x 0.35mm) of local wash-in time constants (
) and regional specific ventilation (sV) were obtained in 5 anaesthetized, paralyzed, and mechanically ventilated rabbits in upright body position at the 4th, 6th, and 8th dorsal vertebral levels with a VT from 4.9±0.3ml/kg, to 7.9±0.4ml/kg (mean±SE). Increasing VT without an increase in minute ventilation resulted in a proportional increase of mean sV up to 65% in all studied lung levels and significantly reduced the scattering of wash-in values. The values had log-normal distributions. The results indicate that an increase in VT decreases non-uniformity of intra-regional ventilatory gas exchange. The findings suggest that SRCT provides a new quantitative tool with high spatial discrimination ability for assessment of changes in peripheral pulmonary gas distribution during mechanical ventilation.
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