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J Appl Physiol (November 27, 2002). doi:10.1152/japplphysiol.00859.2002
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Articles in PresS, published online ahead of print November 27, 2002
J Appl Physiol, 10.1152/jap.00859.2002
Submitted on September 19, 2002
Accepted on November 25, 2002

The ventilatory response to CO2 in high altitude natives and patients with chronic mountain sickness

Marzieh Fatemian1, Alfredo Gamboa2, Fabiola Leon-Velarde2, Maria Rivera-Ch2, Jose-Antonio Palacios2, and Peter A Robbins1*

1 University Laboratory of Physiology, University of Oxford, Oxford, United Kingdom
2 Dpto. De Ciencias Biologicas y Fisiologicas/IIA, Universidad Peruana Cayetano Heredia, Lima, Peru

* To whom correspondence should be addressed. E-mail: peter.robbins{at}physiol.ox.ac.uk.

The ventilatory responses to CO2 of high altitude (HA) natives and patients with chronic mountain sickness (CMS) were studied and compared with sea level (SL) natives living at SL. A multi-frequency binary sequence (MFBS) in end-tidal PCO2 was employed to separate the fast (peripheral) and slow (central) components of the chemoreflex response. The MFBS was imposed against a background of both euoxia (end-tidal PO2 of 100 Torr) and hypoxia (52.5 Torr). Both total and central chemoreflex sensitivity to CO2 in euoxia were higher in HA and CMS subjects compared with SL subjects. Peripheral chemoreflex sensitivity to CO2 in euoxia was higher in HA subjects than in SL subjects. Hypoxia induced a greater increase in total chemoreflex sensitivity to CO2 in SL subjects than in HA and CMS subjects, but peripheral chemoreflex sensitivity to CO2 in hypoxia was no greater in SL subjects than in HA and CMS subjects. Values for the slow (central) time constant were significantly greater for HA and CMS subjects than for SL subjects.




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