Journal of Applied Physiology
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J Appl Physiol (November 2, 2001). doi:10.1152/japplphysiol.00859.2001
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Articles in PresS, published online ahead of print November 2, 2001
J Appl Physiol, 10.1152/jap.00859.2001
Submitted on August 16, 2001
Accepted on October 22, 2001

Critical Developmental Period for Hyperoxia-Induced Blunting of Hypoxic Phrenic Responses in Rats

Ryan W Bavis1*, E B Olson2, and Gordon S Mitchell1

1 Department of Comparative Biosciences, University of Wisconsin, Madison, WI, USA
2 Department of Preventive Medicine, University of Wisconsin, Madison, WI, USA

* To whom correspondence should be addressed. E-mail: bavisr{at}svm.vetmed.wisc.edu.

Hypoxic ventilatory and phrenic responses are reduced in adult rats reared in hyperoxia (60% O2) for the first month of life, but not following hyperoxia as adults. In this study, we identified the developmental window for susceptibility to hyperoxia. Phrenic nerve responses to hypoxia were recorded in anesthetized, vagotomized, paralyzed and ventilated Sprague-Dawley rats (aged 3-4 months) exposed to 60% O2 for the first, second, third or fourth postnatal week. Responses were compared to control rats and rats exposed to 60% O2 for the first month of life. Phrenic minute activity (burst amplitude x frequency) increased less during isocapnic hypoxia (PaO2= 60, 50 and 40 mmHg) in rats exposed to hyperoxia for the first or second week, or the first month, of life (versus control; P<0.01). Functional impairment caused by one week of hyperoxia diminished with increasing age of exposure (P=0.005). Adult hypoxic phrenic responses are impaired by one week of hyperoxia during the first and second postnatal weeks in rats, indicating a developmental window coincident with carotid chemoreceptor maturation.




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