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J Appl Physiol (November 27, 2002). doi:10.1152/japplphysiol.00856.2002
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Articles in PresS, published online ahead of print November 27, 2002
J Appl Physiol, 10.1152/jap.00856.2002
Submitted on September 19, 2002
Accepted on November 25, 2002

Acute and sustained ventilatory responses to hypoxia in high altitude natives living at sea level

Alfredo Gamboa1, Fabiola Leon-Velarde1, Maria Rivera-Ch1, Jose-Antonio Palacios1, Timothy R Pragnell2, David F O'Connor2, and Peter A Robbins2*

1 Dpto. De Ciencias Biologicas y Fisiologicas/IIA, Universidad Peruana Cayetano Heredia, Lima, Peru
2 University Laboratory of Physiology, University of Oxford, Oxford, United Kingdom

* To whom correspondence should be addressed. E-mail: peter.robbins{at}physiol.ox.ac.uk.

High-altitude (HA) natives have blunted ventilatory responses to hypoxia (HVR), but studies differ as to whether this blunting is lost when HA natives migrate to live at sea level (SL), possibly because HVR has been assessed with different durations of hypoxic exposure (acute vs sustained). To investigate this, 50 HA natives (>3,500m, for >20yrs) now resident at SL were compared with 50 SL natives as controls. Isocapnic HVR was assessed using two protocols: protocol 1, progressive step-wise induction of hypoxia over 5-6min; and, protocol 2, sustained (20min) hypoxia (end-tidal PO2=50 Torr). Acute HVR was assessed from both protocols, and sustained HVR from protocol 2. For HA natives, acute HVR was 79% (95%CI 52-106%, p=NS) of SL controls for protocol 1 and 74% (95%CI 52-96%, p<0.05) for protocol 2. By contrast, sustained HVR after 20min hypoxia was only 30% (95%CI -7-67%, p<0.001) of SL control values. The persistent blunting of HVR of HA natives resident at SL is substantially less to acute than sustained hypoxia, when hypoxic ventilatory depression can develop.




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