Journal of Applied Physiology
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J Appl Physiol (February 14, 2003). doi:10.1152/japplphysiol.00849.2002
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Submitted on September 18, 2002
Accepted on February 7, 2003

EFFECT OF EXOGENOUS GROWTH HORMONE AND EXERCISE ON LEAN MASS AND MUSCLE FUNCTION IN CHILDREN WITH BURNS

Oscar E Suman1*, Steve J Thomas2, Judy P Wilkins2, Ronald P Mlcak2, and David N Herndon1

1 Shriners Hospitals for Children, Galveston, Texas, USA; Department of Surgery, The University of Texas Medical Branch, Galveston, Texas, USA
2 Shriners Hospitals for Children, Galveston, Texas, USA

* To whom correspondence should be addressed. E-mail: oesuman{at}utmb.edu.

We tested the hypothesis that the administration of recombinant human growth hormone (rHGH) and exercise would increase lean body mass (LBM) and muscle strength in burned children to a greater extent than rHGH or exercise separately. Children, ages 7 to 17 years, with > 40% body surface area burned were randomized into groups. One group (GHEX, n= 10), participated in a 12-week in-hospital physical rehabilitation program supplemented with an exercise program and received 0.05 mg/kg/day of rHGH. A second exercising group (SALEX, n=13) received saline. A third group (GH, n= 10) received a similar dose of rHGH as GHEX, and participated in a 12-week, home-based physical rehabilitation program without exercise. The fourth group (Saline, n=11) received saline and participated in a 12-week, home-based physical rehabilitation program without exercise. Results. The mean % change (± SEM) in LBM after 12-weeks was not significantly different between GHEX (9.0% ± 2.1), SALEX (5.4% ± 1.6) and GH (5.8% ± 1.8) groups (p = 0.33). However, the mean % change in muscle strength was significantly greater in the GHEX (36.2% ± 5.4) and SALEX (42.6% ± 10.0) groups than in the GH (-7.4% ±4.7) or Saline (6.7% ± 4.4) groups (p = 0.008). Summary. rHGH GHEX, SALEX and GH alone produced similar improvements in LBM. However, muscle strength was only increased via exercise.




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