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J Appl Physiol (February 15, 2002). doi:10.1152/japplphysiol.00841.2001
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Articles in PresS, published online ahead of print February 15, 2002
J Appl Physiol, 10.1152/jap.00841.2001
Submitted on August 10, 2001
Accepted on February 9, 2002

EFFECTS OF VOLATILE ANESTHETICS ON ELASTIC STIFFNESS IN ISOMETRICALLY CONTRACTING VENTRICULAR MYOCARDIUM

Anna E Bartunek1, Victor A Claes2, and Philippe R Housmans3*

1 Department of Anesthesiology, Mayo Foundation, Rochester, MN, USA; Department of Cardiothoracic and Vascular Anesthesia and Intensive Care Medicine, University of Vienna, Vienna, Austria
2 Laboratory of Human Physiology and Pathophysiology, University of Antwerp, Antwerp, Belgium; Laboratory of Human Physiology and Pathophysiology, University of Antwerp, Antwerp, Belgium
3 Department of Anesthesiology, Mayo Foundation, Rochester, MN, USA; Anesthesiology, Mayo Foundation, Rochester, MN, USA

* To whom correspondence should be addressed. E-mail: housmans.philippe{at}mayo.edu.

The effects of halothane, isoflurane and sevoflurane on elastic stiffness, which reflects the degree of cross-bridge attachment, were studied in intact cardiac muscle. Electrically stimulated (0.25 Hz, 25°C), isometrically twitching right ventricular ferret papillary muscles (n=15) were subjected to sinusoidal length oscillations (40 Hz, 0.25 - 0.50 % Lmax peak-to-peak). The amplitude and phase relationship with the resulting force oscillations was decomposed into elastic and viscous components of total stiffness in real time. Increasing [Ca2+]o in the presence of anesthetics to produce peak force equal to control increased elastic stiffness during relaxation which suggests a direct effect of halothane and sevoflurane on cross-bridges.






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