Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (February 15, 2002). doi:10.1152/japplphysiol.00841.2001
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
92/6/2491    most recent
00841.2001v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bartunek, A. E
Right arrow Articles by Housmans, P. R
Right arrow Search for Related Content
PubMed
Right arrow Articles by Bartunek, A. E
Right arrow Articles by Housmans, P. R

Articles in PresS, published online ahead of print February 15, 2002
J Appl Physiol, 10.1152/jap.00841.2001
Submitted on August 10, 2001
Accepted on February 9, 2002

EFFECTS OF VOLATILE ANESTHETICS ON ELASTIC STIFFNESS IN ISOMETRICALLY CONTRACTING VENTRICULAR MYOCARDIUM

Anna E Bartunek1, Victor A Claes2, and Philippe R Housmans3*

1 Department of Anesthesiology, Mayo Foundation, Rochester, MN, USA; Department of Cardiothoracic and Vascular Anesthesia and Intensive Care Medicine, University of Vienna, Vienna, Austria
2 Laboratory of Human Physiology and Pathophysiology, University of Antwerp, Antwerp, Belgium; Laboratory of Human Physiology and Pathophysiology, University of Antwerp, Antwerp, Belgium
3 Department of Anesthesiology, Mayo Foundation, Rochester, MN, USA; Anesthesiology, Mayo Foundation, Rochester, MN, USA

* To whom correspondence should be addressed. E-mail: housmans.philippe{at}mayo.edu.

The effects of halothane, isoflurane and sevoflurane on elastic stiffness, which reflects the degree of cross-bridge attachment, were studied in intact cardiac muscle. Electrically stimulated (0.25 Hz, 25°C), isometrically twitching right ventricular ferret papillary muscles (n=15) were subjected to sinusoidal length oscillations (40 Hz, 0.25 - 0.50 % Lmax peak-to-peak). The amplitude and phase relationship with the resulting force oscillations was decomposed into elastic and viscous components of total stiffness in real time. Increasing [Ca2+]o in the presence of anesthetics to produce peak force equal to control increased elastic stiffness during relaxation which suggests a direct effect of halothane and sevoflurane on cross-bridges.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1966 by the American Physiological Society.