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1 Department of Anesthesiology, The Ohio State University, Columbus, Ohio, USA; Department of Electrical and Computer Engineering, The Ohio State University, Columbus, Ohio, USA
2 Department of Surgery, The Ohio State University, Columbus, Ohio, USA
3 Department of Electrical and Computer Engineering, The Ohio State University, Columbus, Ohio, USA
4 Department of Anesthesiology, The Ohio State University, Columbus, Ohio, USA
5 Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA
* To whom correspondence should be addressed. E-mail: del-rio.4{at}osu.edu.
Changes in myocardial electrical impedance (MEI) and physiological end-points have been correlated during acute ischemia. However, the importance of MEI's early time course is not clear. This study evaluates such significance, by comparing the temporal behavior of MEI during acute total occlusion of the left anterior descending coronary artery (LADa) in anesthetized humans, dogs and pigs. Here, interspecies differences in three MEI parameters (baseline, time to plateau onset, and plateau value normalized by baseline) were evaluated using Kruskal-Wallis ANOVA and post hoc tests (P<0.05). Noteworthy differences in the MEI time to plateau onset were observed: In dogs, MEI ischemic plateau was reached after 46.3±12.9 min of occlusion, a significantly longer period when compared to that of pigs and humans (4.7±1.2 min and 4.1±1.9 min, respectively). However, no differences could be observed between both animal species regarding the normalized MEI ischemic plateau value (15.3±4.7 % in pigs, vs. 19.6±2.6 % in dogs). For all studied MEI parameters, only swine values resembled those of humans. The severity of myocardial supply ischemia, resulting from coronary artery occlusion, is known to be dependent on collateral flow. Thus, as dogs possess a welldeveloped collateral system (unlike humans or pigs), they have shown superior resistance to occlusion of a coronary artery. Here, the early MEI time course after LADa occlusion, represented by the time required to reach ischemic plateau, was proven to reflect such interspecies differences.
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