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J Appl Physiol (March 8, 2002). doi:10.1152/japplphysiol.00830.2001
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Articles in PresS, published online ahead of print March 8, 2002
J Appl Physiol, 10.1152/jap.00830.2001
Submitted on August 7, 2001
Accepted on February 1, 2002

The Influence of Hyperpnea on Airway Surface Fluid Volume and Osmolarity in Normal Man

C. Kotaru1, Rana B Hejal1, J. H Finigan1, A. J Coreno2, M. E Skowronski2, L. J Brianas1, and E. R McFadden, Jr.2*

1 Division of Pulmonary and Critical Care Medicine, University of Colorado Heatlh Science Center, Denver, CO, USA
2 Division of Pulmonary and Critical Care Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA

* To whom correspondence should be addressed. E-mail: erm2{at}po.cwru.edu.

To determine the effect of hyperpnea on the characteristics of periciliary liquid, we collected airway surface fluid (ASF) and measured its osmolarity in 11 normal people while they breathed dry frigid air (-17 ± 1.2 °C) at minute ventilations (VE) of 10, 40 and 80 L/min through a heat exchanger. The ASF was collected at the fifth tracheal ring by absorption onto filter paper pledgets inserted via fiberoptic bronchoscopy. Hyperpnea had no influence on the amount of ASF recovered (ASF volume at a VE of 10 L/min = 12.0 ± 2.0 µL; at 80 L/min = 8.8 ± 1.5 µL, P = 0.28) or its osmolarity (Osm at a VE of 10, 40, and 80 L/min = 326 ± 15, 323 ± 11 and 337 ± 12 mOsm/L, respectively; P = 0.65). These findings demonstrate that the tracheal mucosal of normal subjects does not desiccate during hyperpnea and that hypertonicity of the periciliary fluid does not develop even at high levels of ventilation.




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