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1 Department of Exercise and Sport Science, East Carolina University, Greenville, NC, USA; Human Performance Laboratory, East Carolina University, Greenville, NC, USA
2 Department of Exercise and Sport Science, East Carolina University, Greenville, NC, USA; Department of Physiology, East Carolina University, Greenville, NC, USA; Human Performance Laboratory, East Carolina University, Greenville, NC, USA
3 Department of Surgery, East Carolina University, Greenville, NC, USA
* To whom correspondence should be addressed. E-mail: gavint{at}mail.ecu.edu.
Recently, we observed that muscle capillarization, vascular endothelial growth factor (VEGF) protein, and the VEGF mRNA response to acute exercise were lower in aged compared to young women. We hypothesized that similar age related differences in muscle capillarization and VEGF expression would exist between young and aged men. Skeletal muscle biopsies were obtained from the vastus lateralis prior to and at 4 hr after a sub-maximal exercise bout for the measurement of morphometry and capillarization; and VEGF, KDR and Flt-1 in seven aged (mean age: 65 yrs) and eight young (mean age: 21 yrs) sedentary men. In aged compared to young men, muscle capillary contacts (CC) and capillary-to-fiber perimeter exchange index (CFPE) were lower regardless of fiber type. Muscle VEGF mRNA and protein were lower in aged men both at rest and 4 hr post-exercise. Exercise increased muscle VEGF mRNA and protein and KDR mRNA independent of age group. There were no effects of exercise or age on muscle Flt-1 mRNA or protein or KDR protein. These results confirm that skeletal muscle capillarization and VEGF expression are lower in aged compared to young men.
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