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J Appl Physiol (December 6, 2002). doi:10.1152/japplphysiol.00825.2002
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Articles in PresS, published online ahead of print December 6, 2002
J Appl Physiol, 10.1152/jap.00825.2002
Submitted on September 11, 2002
Accepted on December 3, 2002

High concentrations of 17{beta}-estradiol attenuate the exercise pressor reflex in male cats

Petra M Schmitt1* and Marc P Kaufman1

1 Department of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, Davis, CA, USA

* To whom correspondence should be addressed. E-mail: pmschmitt{at}ucdavis.edu.

Previously, intravenous injection of 17{beta}-estradiol in decerebrate male cats was found to attenuate central command but not the exercise pressor reflex. This latter finding was surprising because the dorsal horn, the spinal site receiving synaptic input from thin fiber muscle afferents, is known to contain estrogen receptors. We were prompted, therefore, to re-examine this issue. Instead of injecting 17{beta}-estradiol intravenously, we applied it topically to the L7 and S1 spinal cord of male decerebrate cats. We found that topical application (150-200 µl) of 17{beta}-estradiol in concentrations of 0.01, 0.1 and 1 µg/ml had no effect on the exercise pressor reflex, whereas a concentration of 10 µg/ml attenuated the reflex. We conclude that in male cats estrogen can only attenuate the exercise pressor reflex in concentrations that exceed the physiological level.




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