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Articles in PresS, published online ahead of print December 14, 2001
J Appl Physiol, 10.1152/jap.00824.2001
Submitted on August 3, 2001
Accepted on December 10, 2001
1 Kinesiology & Applied Physiology, University of Colorado at Boulder, Boulder, CO, USA
2 Kinesiology & Applied Physiology, University of Colorado at Boulder, Boulder, CO, USA; Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
* To whom correspondence should be addressed. E-mail: htanaka{at}mail.utexas.edu.
Carotid artery intima-media thickness (IMT), an independent risk factor for stroke, increases with age. Habitual exercise is associated with a lower prevalence of stroke, but it is unclear if this protective effect could be mediated through a favorable influence on carotid IMT. We examined this possibility using both cross-sectional and intervention approaches. First, 137 healthy men aged 18-77 yrs who were either sedentary or endurance-trained were studied. In both groups, carotid IMT and IMT/lumen ratio were progressively higher with age (P<0.05). There were no significant differences in measures of carotid IMT between sedentary and endurance-trained men at any age. Carotid systolic blood pressure increased progressively with age, and was related to carotid IMT (r=0.63, P<0.01). Second, 18 healthy sedentary subjects (54±2 yrs) were studied before and after 3-months of endurance training. Carotid IMT, IMT/lumen ratio, and carotid systolic blood pressure did not change with exercise intervention. Our results do not support the hypothesis that regular aerobic exercise exerts its protective effect against stroke by attenuating the age-related increase in carotid IMT. This lack of effect on carotid IMT may be due to the apparent inability of habitual exercise to prevent or reduce the age-associated elevation in carotid distending pressure.
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