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J Appl Physiol (October 12, 2001). doi:10.1152/japplphysiol.00819.2001
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Articles in PresS, published online ahead of print October 12, 2001
J Appl Physiol, 10.1152/jap.00819.2001
Submitted on August 2, 2001
Accepted on October 8, 2001

EFFECTS OF CAROTID AND AORTIC CHEMORECEPTOR DENERVATION IN NEWBORN PIGLETS

Alexandre Serra1, Daniel T Brozoski1, Matthew R Hodges1, Scott T Roethle1, Ralph A Franciosi2, and Hubert V Forster3*

1 Physiology, Medical College of Wisconsin, Milwaukee, WI, USA
2 Pathology, Medical College of Wisconsin, Milwaukee, WI, USA
3 Physiology, Medical College of Wisconsin, Milwaukee, WI, USA; Physiology, Zablocki VA Medical Center, Milwaukee, WI, USA

* To whom correspondence should be addressed. E-mail: Alexandre.Serra{at}mailbox.tu-dresden.de.

The objective of the present study was to test the hypothesis in neonatal piglets that there would be no hypoventilation after sham denervation or aortic denervation (AOD) alone, but there would be transient hypoventilation after carotid body denervation (CBD) and the hypoventilation would be greatest after combined carotid and aortic denervation (CBD+AOD). There was a significant (P<0.05) hypoventilation in CBD and CBD+AOD piglets denervated at 5, 15 and 25 days of age. The hypoventilation in CBD+AOD piglets denervated at 5 days of age was greater (P<0.05) than all other groups. Conversely, sham and AOD piglets did not hypoventilate after denervation. Injections of NaCN showed that aortic chemoreceptors were a site of recovery of peripheral chemosensitivity after CBD. This aortic NaCN response was abolished by prior injection of a serotonin 5a receptor blocker. Residual peripheral chemosensitivity after CBD+AOD was localized to the left ventricle. We conclude that: 1) aortic chemoreceptors contribute to eupneic breathing in piglets that were carotid denervated at 5 days of age, and 2) there are multiple sites of residual peripheral chemosensitivity after CBD.




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