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J Appl Physiol (January 17, 2003). doi:10.1152/japplphysiol.00810.2002
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Submitted on September 6, 2002
Accepted on January 11, 2003

Effects of muscle metaboreceptor stimulation on cutaneous blood flow from glabrous and non-glabrous skin in mildly heated humans

Narihiko Kondo1*, Shuji Yanagimoto1, Takeshi Nishiyasu2, and Craig G Crandall3

1 Faculty of Human Development, Kobe University, Laboratory for Applied Human Physiology, Kobe, Japan
2 University of Tsukuba, Institute of Health and Sport Sciences, Tsukuba, Japan
3 Presbyterian Hospital of Dallas, Institute for Exercise and Environmental Medicine, Dallas, USA

* To whom correspondence should be addressed. E-mail: Kondo{at}kobe-u.ac.jp.

Given differences in sympathetic innervation to glabrous and non-glabrous skin, we tested the hypothesis that muscle metaboreceptor regulation of cutaneous vascular conductance (CVC) differs between these skin regions. Subjects (n=21) performed isometric handgrip exercise (IHG; 50% maximal voluntary contraction for 60 sec), followed by 2 min of post-exercise ischemia. Throughout IHG and post-exercise ischemia, CVC was measured from glabrous (palm) and non-glabrous (forearm and chest) regions contralateral to the exercising arm. These procedures were conducted after the subjects had been exposed to an ambient temperature of 35°C and a relative humidity of 50% for 60 min. These thermal conditions were intended to cause slight increases in cutaneous blood flow via sympathetic withdrawal. Esophageal, sublingual, and mean skin temperatures did not change markedly during IHG or post-exercise ischemia. During IHG, forearm CVC did not change, chest CVC increased slightly, and palm CVC decreased substantially (from 100% to 34.8±3.5%; p=0.001). During muscle metaboreceptor stimulation due to post-exercise ischemia, CVC from non-glabrous regions returned to pre-exercise baselines, whereas CVC at the palm remained below pre-exercise baseline (68.2±4.2%; p=0.001 relative to pre-exercise baseline). These results indicate that in mildly heated humans muscle metaboreflex stimulation is capable of modulating CVC in glabrous, but not in non-glabrous skin.




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