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J Appl Physiol (November 10, 2005). doi:10.1152/japplphysiol.00809.2005
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Submitted on July 8, 2005
Accepted on November 8, 2005

Comparison of postnatal lung growth and development between C3H/HeJ and C57BL/6J mice

Shawn E. Soutiere1 and Wayne Mitzner1*

1 Department of Environmental Health Sciences Division of Physiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA

* To whom correspondence should be addressed. E-mail: wmitzner{at}jhsph.edu.

Previous work by our group has demonstrated substantial differences in lung volume and morphometric parameters between inbred mice. Specifically, adult C3H/HeJ (C3) have a 50% larger lung volume and 30% greater mean linear intercept than C57BL/6J (B6) mice. Although much of lung development occurs postnatally in rodents, it is uncertain at what age the differences between these strains become manifest. In this study we performed quasi-static pressure-volume (P-V) curves and morphometric analysis on neonatal mice. Lungs from anesthetized mice were degassed in vivo using absorption of 100% O2. P-V curves were then recorded in situ. The lungs were then fixed by instillation of Zenkers solution at a constant transpulmonary pressure. The left lung from each animal was used for morphometric determination of mean airspace chord length (Lma). We found that the lung volume of C3 mice was substantially greater than B6 mice at all ages. In contrast, there was no difference in Lma (62.7 µm in C3 and 58.5 mm in B6) of 3-day-old mice. With increasing age (8 d) there was a progressive decrease in the Lma of both strains, with the magnitude of the decrease in B6 Lma mice exceeding that of C3. C3 lung volume remained 50% larger. The combination of parenchymal architectural similarity with lung air volume differences and different rates of alveolar septation support the hypothesis that lung volume and alveolar dimensions are independently regulated.




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