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Articles in PresS, published online ahead of print June 14, 2002
J Appl Physiol, 10.1152/jap.00809.2001
Submitted on August 1, 2001
Accepted on June 12, 2002
1 Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA
2 Department of Medicine, University of California, San Diego, La Jolla, California, USA
3 Functional Genomics Laboratory, Medical College of Ohio, Toledo, Ohio, USA
* To whom correspondence should be addressed. E-mail: ngonzale{at}kumc.edu.
Oxygen transport during maximal exercise was studied in rats bred for extremes of exercise endurance, to determine whether maximal O2 uptake (VOO2max) was different in high (HCR) and low capacity runners (LCR), and if so, which were the phenotypes responsible for the difference. VOO2max was determined in 5 HCR and 6 LCR female rats using a progressive treadmill exercise protocol at PIOIO2 of 147 (Nx) and 70 Torr (Hx). Normoxic VOO2max (ml/min.kg) was 64.4±0.4 and 57.6±1.5 (p<0.05), while VOO2max in Hx was 42.7±0.8 and 35.3±1.5 (p<0.05) in HCR and LCR, respectively. Lack of significant differences between HCR and LCR in alveolar ventilation, alveolar-to-arterial PO2 difference, or lung O2 diffusing capacity indicated that neither ventilation nor efficacy of gas exchange contributed to the difference inVOO2max between groups. Maximal rate of blood O2 convection (cardiac output times arterial blood O2 content) was also similar in both groups. The major difference observed was in capillary-to-tissue O2 transfer: both the O2 extraction ratio (0.81±0.002 in HCR, 0.74 ± 0.009 in LCR, p<0.001) and the tissue diffusion capacity (1.18 ± 0.09 in HCR and 0.92 ± 0.05 ml/min/Kg/Torr in LCR, p<0.01) were significantly higher in HCR. The data indicate that selective breeding for exercise endurance resulted in higher VOO2max mostly associated with a higher transfer of O2 at the tissue level.
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