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J Appl Physiol (June 30, 2002). doi:10.1152/japplphysiol.00807.2001
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Articles in PresS, published online ahead of print June 30, 2002
J Appl Physiol, 10.1152/jap.00807.2001
Submitted on July 31, 2001
Accepted on April 10, 2002

Circadian Pancreatic Enzyme Pattern and Relationship between Secretory and Intestinal Motor Activity in Fasting Humans

Jutta Keller1* and Peter Layer1

1 Department of Internal Medicine, Israelitic Hospital, Hamburg, Germany

* To whom correspondence should be addressed. E-mail: keller{at}ik-h.de.

Non-parallel pancreatic enzyme output has been observed in response to stimulation. Aims: To determine whether the circadian or wake-sleep cycle influence the relationship among pancreatic enzymes or between pancreatic secretory and jejunal motor activity. Methods: Amylase and protease outputs and proximal jejunal motility index were measured during consecutive daytime and nighttime periods (24 h overall) in 7 fasting healthy volunteers using oro-jejunal multilumen intubation. Results: Enzyme outputs were correlated tightly during daytime phases of wakefulness and nighttime phases of sleep (r>0.72, p<0.001). During nocturnal phases of wakefulness outputs of proteases (r=0.84, p<0.001), but not of amylase and trypsin (r=0.12) remained associated. Nocturnally, particularly during sleep, pancreatic secretory activity was directly correlated with jejunal motility index (r>0.50, p<0.001). Conclusions: Parallel secretion of pancreatic enzymes dominates throughout the circadian cycle. Non-parallel secretion during nocturnal phases of wakefulness may be due to merely circadian effects or to the coupling of the wake-sleep and the circadian cycle. The association between fluctuations of secretory and motor activity appears to be particularly tight during the night.




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