Journal of Applied Physiology Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (April 19, 2002). doi:10.1152/japplphysiol.00807.2001
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
93/2/592    most recent
00807.2001v2
00807.2001v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Keller, J.
Right arrow Articles by Layer, P.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Keller, J.
Right arrow Articles by Layer, P.

Articles in PresS, published online ahead of print April 19, 2002
J Appl Physiol, 10.1152/jap.00807.2001
Submitted on July 31, 2001
Accepted on December 31, 1969

Circadian Pancreatic Enzyme Pattern and Relationship between Secretory and Intestinal Motor Activity in Fasting Humans

Jutta Keller1* and Peter Layer1

1 Department of Internal Medicine, Israelitic Hospital, Hamburg, Germany

* To whom correspondence should be addressed. E-mail: keller{at}ik-h.de.

Non-parallel pancreatic enzyme output has been observed in response to stimulation. Aims: To determine whether the circadian or wake-sleep cycle influence the relationship among pancreatic enzymes or between pancreatic secretory and jejunal motor activity. Methods: Amylase and protease outputs and proximal jejunal motility index were measured during consecutive daytime and nighttime periods (24 h overall) in 7 fasting healthy volunteers using oro-jejunal multilumen intubation. Results: Enzyme outputs were correlated tightly during daytime phases of wakefulness and nighttime phases of sleep (r>0.72, p<0.001). During nocturnal phases of wakefulness outputs of proteases (r=0.84, p<0.001), but not of amylase and trypsin (r=0.12) remained associated. Nocturnally, particularly during sleep, pancreatic secretory activity was directly correlated with jejunal motility index (r>0.50, p<0.001). Conclusions: Parallel secretion of pancreatic enzymes dominates throughout the circadian cycle. Non-parallel secretion during nocturnal phases of wakefulness may be due to merely circadian effects or to the coupling of the wake-sleep and the circadian cycle. The association between fluctuations of secretory and motor activity appears to be particularly tight during the night.




This article has been cited by other articles:


Home page
 jvdiHome page
G. Piccione, C. Giannetto, F. Fazio, and E. Giudice
Daily rhythm of serum lipase and {alpha}-amylase activity in fed and fasted dogs
J Vet Diagn Invest, November 1, 2008; 20(6): 795 - 799.
[Abstract] [Full Text] [PDF]

Home page
 Poult. Sci.Home page
F. Zhao, S. S. Hou, H. F. Zhang, and Z. Y. Zhang
Effects of Dietary Metabolizable Energy and Crude Protein Content on the Activities of Digestive Enzymes in Jejunal Fluid of Peking Ducks
Poult. Sci., August 1, 2007; 86(8): 1690 - 1695.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
M. Cloutier, D. Gingras, and M. Bendayan
Internalization and Transcytosis of Pancreatic Enzymes by the Intestinal Mucosa
J. Histochem. Cytochem., July 1, 2006; 54(7): 781 - 794.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
J Keller and P Layer
Human pancreatic exocrine response to nutrients in health and disease
Gut, July 1, 2005; 54(suppl_6): 1 - 28.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1966 by the American Physiological Society.