| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Institute of Sports Medicine, Copenhagen, Bispebjerg Hospital, Copenhagen, Denmark
2 Bispebjerg Hopital, Institute Sports Medicine, Copenhagen, Denmark
3 Osteoporosis and Metabolic Bone Unit, Dept of Clinical Biochemistry, Copenhagen University Hospitals, Denmark
4 Molecular Physiology, University of Dundee, Dundee, United Kingdom
5 School of Biomedical Scinces, University of Nottingham, United Kingdom
6 School of Biomedical Scinces, University of Nottingham, Derby, United Kingdom
* To whom correspondence should be addressed. E-mail: b.miller{at}auckland.ac.nz.
In general there is a higher incidence of musculoskeletal injuries during physical activity in women than in men. We hypothesized that in women rates of tendon collagen synthesis would be lower than in men at rest and after exercise, especially in the later luteal phase when estrogen and progesterone concentrations are higher than the early follicular phase. We studied tendon collagen fractional synthesis rate (FSR) in 15 young, healthy female subjects in either the early follicular (FP, n=8) or the late luteal phase (LP, n=7) 72 h after an acute bout of one-legged exercise (60 min kicking at 67% Wmax) (72 h) and compared the results to those previously obtained for men. Samples were taken from the patellar tendon in both the exercised and rested legs to determine collagen fractional synthesis rate (FSR) by the incorporation of 15N-proline into tendon collagen hydroxyproline. There was no effect of menstrual phase on tendon collagen synthesis either at rest or after exercise. However, there was a significant difference between women and men at rest (women = 0.025±0.002%.h-1; men = 0.045±0.008%.h-1, P<0.05) and 72 h after exercise (women = 0.027±0.005%.h-1; men = 0.058±0.008%.h-1). Furthermore, rest and 72 h tendon collagen synthesis was not different in women, while in men tendon collagen synthesis remained significantly elevated 72 h after exercise. It is concluded that both in the resting state and after exercise, tendon collagen FSR is lower in women than in men, which may contribute to a lower rate of tissue repair after exercise.
This article has been cited by other articles:
|
|
 |
|
  N. A. Burd, J. E. Tang, D. R. Moore, and S. M. Phillips Exercise training and protein metabolism: influences of contraction, protein intake, and sex-based differences J Appl Physiol, May 1, 2009; 106(5): 1692 - 1701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Sullivan, C. C. Carroll, B. Jemiolo, S. W. Trappe, S. P. Magnusson, S. Dossing, M. Kjaer, and T. A. Trappe Effect of acute resistance exercise and sex on human patellar tendon structural and regulatory mRNA expression J Appl Physiol, February 1, 2009; 106(2): 468 - 475. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. LeMoine, J. D. Lee, and T. A. Trappe Impact of sex and chronic resistance training on human patellar tendon dry mass, collagen content, and collagen cross-linking Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2009; 296(1): R119 - R124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Carroll, J. M. Dickinson, J. M. Haus, G. A. Lee, C. J. Hollon, P. Aagaard, S. P. Magnusson, and T. A. Trappe Influence of aging on the in vivo properties of human patellar tendon J Appl Physiol, December 1, 2008; 105(6): 1907 - 1915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Bryant, R. A. Clark, S. Bartold, A. Murphy, K. L. Bennell, E. Hohmann, S. Marshall-Gradisnik, C. Payne, and K. M. Crossley Effects of estrogen on the mechanical behavior of the human Achilles tendon in vivo J Appl Physiol, October 1, 2008; 105(4): 1035 - 1043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kjaer and M. Hansen The mystery of female connective tissue J Appl Physiol, October 1, 2008; 105(4): 1026 - 1027. [Full Text] [PDF]
|
|
|
|
 |
|
 K. Knobloch, L. Schreibmueller, R. Meller, K. H. Busch, M. Spies, and P. M. Vogt Superior Achilles Tendon Microcirculation in Tendinopathy Among Symptomatic Female Versus Male Patients Am. J. Sports Med., March 1, 2008; 36(3): 509 - 514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Trappe, C. C. Carroll, B. Jemiolo, S. W. Trappe, S. Dossing, M. Kjaer, and S. P. Magnusson Cyclooxygenase mRNA expression in human patellar tendon at rest and after exercise Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R192 - R199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Trappe Sex inequity in tendon metabolism? J Appl Physiol, February 1, 2007; 102(2): 507 - 507. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
