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J Appl Physiol (March 1, 2002). doi:10.1152/japplphysiol.00795.2001
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Articles in PresS, published online ahead of print March 1, 2002
J Appl Physiol, 10.1152/jap.00795.2001
Submitted on July 30, 2001
Accepted on February 25, 2002

Gas bubbles in rats after heliox saturation and different decompression steps and rates

Steffen Skogland1, Kare Segadal1, Harald Sundland1, and Arvid Hope1*

1 NUI AS, Bergen, Norway

* To whom correspondence should be addressed. E-mail: ah{at}nui.no.

The effects of pressure reduction, decompression rate and repeated exposure on venous gas bubble formation were determined in five groups (GI-GV) of conscious and freely moving rats in an heliox atmosphere. Bubbles were recorded with an ultrasound Doppler probe implanted around the inferior caval vein. The rats were held for 16 h at 0.4 MPa (GI), 0.5 MPa (GII and GIII), 1.7 MPa (GIV) or 1.9 MPa (GV), followed by decompression to 0.1 MPa in GI-GIII and to 1.1 MPa in GIV and GV. A greater decompression step, but at the same rate (GII versus GI and GIVb versus GIVa), resulted in significantly more bubbles (p<0.01). A twofold decompression step resulted in equal amount of bubbles when decompressing to 1.1 MPa compared with 0.1 MPa. The faster decompression in GII and GVa (10.0 kPa/s) resulted in significantly more bubbles (p<0.01) compared to GIII and GVb (2.2 kPa/s). No significant difference was observed in cumulative bubble score when comparing first and second exposure. With the present animal model different decompression regimes may be evaluated.






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