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J Appl Physiol (October 26, 2001). doi:10.1152/japplphysiol.00794.2001
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Articles in PresS, published online ahead of print October 26, 2001
J Appl Physiol, 10.1152/jap.00794.2001
Submitted on July 30, 2001
Accepted on October 23, 2001

Gene expression of adrenomedullin in failing myocardium: comparison to atrial natriuretic peptide

Anselm T Baumer1*, Christina Schumann1, Bodo Cremers2, Gabi Itter3, Wolfgang Linz3, Friedrich Jockenhovel4, and Michael Bohm2

1 Klinik III fur Inner Medizin, Universitat zu Koln, Cologne, Germany
2 Innere Medizin III, Universitatskliniken des Saarlandes, Homburg/Saar, Germany
3 Cardiovascular Research, Aventis Pharma, Frankfurt/Main, Germany
4 Klinik II fur Innere Medizin, Universitat zu Koln, Cologne, Germany

* To whom correspondence should be addressed. E-mail: Anselm.Baeumer{at}medizin.uni-koeln.de.

The expression of adrenomedullin (AM) and atrial natriuretic factor (ANF) were investigated in myocardium of a rat model of chronic ischemic heart failure (CHF) compared to sham operated controls (sham). In addition, human myocardium of patients with end-stage heart failure due to idiopathic dilated cardiomyopathy (DCM) in comparison to myocardium of normal subjects (NF) was studied. In CHF similar AM levels but increased ANF expression were observed in left ventricular myocardium, as assessed by semiquantitative PCR. Functional experiments with freshly excised papillary muscles showed no influence of AM on myocardial contractility. In NF human myocardium, the expression of AM mRNA was 3-fold higher in atrial compared to ventricular tissue. In analogy, ANF mRNA was increased by approximately 15-fold in atrial tissue. In DCM, the expression of AM was significantly increased in right and left ventricles as compared to NF. In parallel, ventricular ANF expression was enhanced.




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