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J Appl Physiol (October 22, 2004). doi:10.1152/japplphysiol.00790.2004
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Submitted on July 27, 2004
Accepted on October 21, 2004

Ascorbic Acid Does Not Affect The Age-Associated Reduction In Maximal Cardiac Output And Oxygen Consumption In Healthy Adults

Christopher Bell1*, John M Carson1, Nathaniel W Motte1, and Douglas R Seals1

1 Department of Integrative Physiology, University of Colorado, Boulder, CO, USA

* To whom correspondence should be addressed. E-mail: Christopher.Bell{at}Colorado.edu.

Maximal aerobic capacity (VO2max) decreases progressively with age primarily because of a reduction in maximal cardiac output (Qmax). This age-associated decline in VO2max may be partially mediated by the development of oxidative stress that can suppress {beta}-adrenergic receptor responsiveness and consequently reduce Qmax. To test this hypothesis VO2max (indirect calorimetry) and Qmax (open-circuit acetylene breathing) were determined in 12 young (23±1 years, mean±SE) and 10 older (61±1 years) adults following systemic infusion of either saline (control) and/or the powerful antioxidant ascorbic acid (acute: bolus 0.06; drip 0.02 g/kg fat free mass), and following chronic 30-day oral administration of ascorbic acid (500 mg/day). Plasma ascorbic acid concentration was not different between young and older adults and was increased similarly, independent of age ({Delta}acute=1055±117%; {Delta}chronic=62±19%). Oxidized low-density lipoprotein concentration was greater (P<0.001) in older (57±5 U/L) compared with young (34±3 U/L) adults and was reduced in both groups (P<0.02) following acute ({Delta}=-6±2%) but not chronic (P=0.18) ascorbic acid administration. Control (baseline) VO2max and Qmax were positively related (r=0.76, P<0.001), and were lower (P<0.05) in older (34±2 ml/kg/min; 16.1±1.1 l/min) compared with young (43±3 ml/kg/min; 20.2±0.9 l/min) adults. Following ascorbic acid administration neither VO2max (young-acute=41±2; young-chronic=42±2; older-acute=34±2; older-chronic=34±2) nor Qmax (young-acute=20.1±0.9; young-chronic=19.1±0.8; older-acute=16.2±1.1; older-chronic=16.6±1.4) were changed. These data suggest that ascorbic acid administration does not affect the age-associated reduction in Qmax and VO2max.




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