Journal of Applied Physiology Journal of Applied Physiology
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J Appl Physiol (February 21, 2003). doi:10.1152/japplphysiol.00790.2002
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Submitted on August 28, 2002
Accepted on February 18, 2003

Prolonged head-down tilt exposure reduces maximal cutaneous vasodilator and sweating capacity in humans

Craig G Crandall1*, Manabu Shibasaki2, Thad E Wilson2, Jian Cui2, and Benjamin D Levine1

1 Presbyterian Hospital of Dallas, Institute for Exercise and Environmental Medicine, Dallas, TX, USA; University of Texas Southwestern Medical Center, Department of Internal Medicine, Dallas, TX, USA
2 Presbyterian Hospital of Dallas, Institute for Exercise and Environmental Medicine, Dallas, TX, USA

* To whom correspondence should be addressed. E-mail: craigcrandall{at}texashealth.org.

Cutaneous vasodilation and sweat rate responses are reduced during a thermal challenge following simulated and actual microgravity exposure. The effects of microgravity exposure on cutaneous vasodilator capacity and on sweat gland function are unknown. The purpose of this study was to test the hypothesis that simulated microgravity exposure, using the 6° head-down tilt (HDT) bed rest model, reduces maximal forearm cutaneous vascular conductance (FVC) and sweat gland function, and that exercise during HDT preserves these responses. To test these hypotheses 20 subjects were exposed to 14 days of strict HDT bed rest. Twelve of those subjects exercised (supine cycle ergometry) at 75% of pre-bed rest heart rate maximum for 90 min a day throughout HDT bed rest. Prior to and following HDT bed rest, maximal FVC was measured, via plethysmography, by heating the entire forearm to 42° C for 45 min. Sweat gland function was assessed by administering 10-6 to 2 M acetylcholine (9 doses) via intradermal microdialysis while simultaneously monitoring sweat rate over the microdialysis membranes. In the non-exercise group maximal FVC and maximal stimulated sweat rate were significantly reduced following HDT bed rest. In contrast, these responses were unchanged in the exercise group. These data suggest that 14 days of simulated microgravity exposure, using the HDT bed rest model, reduces cutaneous vasodilator and sweating capacity, while aerobic exercise training during HDT bed rest preserves these responses.




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