Journal of Applied Physiology
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J Appl Physiol (September 28, 2006). doi:10.1152/japplphysiol.00776.2006
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Submitted on July 13, 2006
Accepted on September 11, 2006

Similar acute molecular responses to equivalent volumes of isometric, lengthening or shortening mode resistance exercise

Toni Maria Garma1, Cori Ann Kobayashi1, Fadia Haddad1, Gregory R. Adams2, Paul W Bodell1, and Kenneth M. Baldwin1*

1 Physiology and Biophysics, University of California, Irvine, Irvine, California, United States
2 Department of Physiology & Biophysics, University of California, Irvine, Irvine, California, United States

* To whom correspondence should be addressed. E-mail: kmbaldwi{at}uci.edu.

The present study was undertaken to test the hypothesis that the contraction mode of action (static - isometric [ISO], shortening - concentric [CON], or lengthening- eccentric [ECC]) used to stress the muscle provides a differential mechanical stimulus eliciting greater or lesser degrees of anabolic response at the initiation of a resistance training program. We performed an acute resistance training study in which different groups of rodents completed four training sessions in either the ISO, CON or ECC mode of contraction under conditions of activation and movement specifically designed to elicit equivalent volumes of force accumulation. The results of this experiment indicate that the three modes of contraction produced nearly identical cell signaling indicative of an anabolic response involving factors such as: increased levels of mRNA for insulin-like growth factor -I (IGF-I), pro-collagen III {alpha}1, decreased myostatin mRNA and increased total RNA concentration. The resulting profiles collectively provide evidence that pure mode of muscle action, in-and-of itself, does not appear to be a primary variable in determining the efficacy of increased loading paradigms with regard to the initiation of selected muscle anabolic responses.




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