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J Appl Physiol (October 12, 2006). doi:10.1152/japplphysiol.00763.2006
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Submitted on July 10, 2006
Accepted on September 13, 2006

Visualizing lung function with positron emission tomography

R Scott Harris1* and Daniel P Schuster2

1 Department of Medicine (Pulmonary and Critical Care Unit), Massachusetts General Hospital, Boston, Massachusetts, United States
2 Department of Internal Medicine and the Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States

* To whom correspondence should be addressed. E-mail: rharris{at}partners.org.

Positron emission tomography (PET) provides three-dimensional images of the distributions of radionuclides that have been inhaled or injected into the lungs. By using radionuclides with short half-lives, the radiation exposure of the subject can be kept small. By following the evolution of the distributions of radionuclides in gases or compounds that participate in lung function, information about such diverse lung functions as regional ventilation, perfusion, shunt, gas fraction, capillary permeability, inflammation, and gene expression can be inferred. Thus, PET has the potential to provide information about the links between cellular function and whole lung function in vivo. In this paper, recent advancements in PET methodology and techniques and information about lung function that have been obtained with these techniques are reviewed.




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