Journal of Applied Physiology AJP: Endocrinology and Metabolism
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J Appl Physiol (January 31, 2003). doi:10.1152/japplphysiol.00758.2002
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Submitted on August 19, 2002
Accepted on January 22, 2003

Assessment of Exhaled Nitric Oxide Kinetics in Healthy Infants

Tanya M Martinez*, Andrea D Weist, Tamica Williams, Charles Clem, Philip Silkoff, and Robert S Tepper

* To whom correspondence should be addressed. E-mail: tanmarti{at}iupui.edu.

Background: Exhaled nitric oxide (FENO) measurements provide a noninvasive approach to the evaluation of airway inflammation. Flow-independent NO exchange parameters (DNO-airway NO transfer factor, CwNO-airway wall NO concentration) can be estimated from two FENO measurements at low flows, and may elucidate mechanisms of disturbances in NO exchange. Methods: We measured FENO in sedated infants using an adaptation of a raised lung volume rapid thoracic compression technique which creates forced expiration through a mass flow controller that lasts 5-10 sec, at a constant preset flow. We measured FENO at expired flows of 50, 25, and 15 ml/sec in five healthy infants (7-31 mo). Results: Median FENO increased (24, 40, and 60 ppb) with decreasing expiratory flows (50, 25, and 15 ml/sec). Group median (range) for DNO and CwNO were 12.7 (3.2-37)nl/sec/ppbX10-3, and 108.9 (49-385) ppb, respectively, similar to values reported in healthy adults. Conclusion: Exhaled NO is flow dependent and parameters of exhaled NO kinetics can be assessed in infants, and are similar to values described in adults.




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