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J Appl Physiol (August 29, 2003). doi:10.1152/japplphysiol.00748.2003
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Submitted on July 18, 2003
Accepted on August 26, 2003

ANGIOGENIC GROWTH FACTOR RESPONSE TO ACUTE SYSTEMIC EXERCISE IN HUMAN SKELETAL MUSCLE

Timothy P Gavin1*, Christopher B Robinson2, Robert C Yeager2, Justin A England2, L. Wiley Nifong3, and Robert C Hickner1

1 Department of Exercise and Sport Science, East Carolina University, Greenville, NC, USA; Department of Physiology, East Carolina University, Greenville, NC, USA
2 Department of Exercise and Sport Science, East Carolina University, Greenville, NC, USA
3 Department of Surgery, East Carolina University, Greenville, NC, USA

* To whom correspondence should be addressed. E-mail: gavint{at}mail.ecu.edu.

We investigated if acute systemic exercise increases VEGF, KDR and Flt-1 mRNA and VEGF protein in sedentary humans. Twelve (N=12) sedentary subjects were recruited and performed 1 hr of acute, cycle ergometer exercise at 50% of VO2MAX. Muscle biopsies were obtained from the vastus lateralis prior to exercise and at 0, 2, and 4 hr post-exercise. Acute exercise significantly increased VEGF mRNA at 2 and 4 hr, and KDR and Flt-1 mRNA at 4 hr post-exercise. The sustained increase in VEGF mRNA through 4 hr and the increases in KDR and Flt-1 at 4 hr are different than their respective time course responses in rats. In contrast to the increase in VEGF mRNA post-exercise, VEGF protein levels were decreased at 0 hr post-exercise. These results provide evidence in humans that: 1) VEGF, KDR, and Flt-1 mRNA are increased by acute systemic exercise; 2) the time course of the VEGF, KDR, and Flt-1 mRNA responses are different than those previously reported in rats; and 3) VEGF protein is decreased immediately following exercise.




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